Erichev V P
Research Institute of Eye Diseases, Moscow, Russia.
Vestn Oftalmol. 2021;137(5. Vyp. 2):354-360. doi: 10.17116/oftalma2021137052354.
Primary open-angle glaucoma (POAG) is among the most common causes of irreversible loss of visual functions, its early diagnosis and treatment present great difficulties. POAG development involves many mechanical, hemodynamic and metabolic factors. The main approach to its treatment is reduction and normalization of the intraocular pressure (IOP), starting with local antihypertensive therapy. But since glaucoma requires life-long management, lengthy topical therapy can itself become the cause of many serious issues. Most often, they include achieving consistent normalization of IOP, systemic and local adverse events, difficulties with patient compliance, decreased quality of life, increased risks of the glaucoma surgeries. Ophthalmological practice and research continue to demonstrate the need for changing the paradigm of POAG treatment.
原发性开角型青光眼（POAG）是导致不可逆视力功能丧失的最常见原因之一，其早期诊断和治疗存在很大困难。POAG的发展涉及许多机械、血流动力学和代谢因素。其主要治疗方法是降低眼压（IOP）并使其正常化，首先从局部抗高血压治疗开始。但由于青光眼需要终身管理，长期的局部治疗本身可能成为许多严重问题的原因。最常见的问题包括实现IOP持续正常化、全身和局部不良事件、患者依从性困难、生活质量下降、青光眼手术风险增加。眼科实践和研究不断表明需要改变POAG的治疗模式。
