Altobelli D E, Lorente C A, Handren J H, Young J, Donoff R B, May J W
J Oral Maxillofac Surg. 1987 Jan;45(1):27-33. doi: 10.1016/0278-2391(87)90082-6.
Microvascular and free rib grafts were placed in 4.5 cm defects in an edentate mandibular body defect 18 to 28 days after completion of 50 Gy of irradiation from a 60Co source. The animals were sacrificed from two to forty weeks postoperatively and evaluated clinically, radiographically, and histologically. There was a marked difference in the alveolar mucosal viability with the two grafts. Mucosal dehiscence was not observed over any of the microvascular grafts, but was present in seven-eighths of the free grafts. Union of the microvascular bone graft to the host bone occurred within six weeks. In contrast, after six weeks the free graft was sequestered in all the animals. An unexpected finding with both types of graft was the marked subperiosteal bone formation. This bone appeared to be derived from the host bed, stabilizing and bridging the defects bilaterally. The results suggest that radiated periosteum may play an important role in osteogenesis.
在接受来自钴 - 60源的50Gy照射18至28天后，将微血管和游离肋骨移植物植入无牙下颌骨体部4.5厘米的缺损处。术后2至40周处死动物，并进行临床、影像学和组织学评估。两种移植物的牙槽黏膜活力存在显著差异。在任何微血管移植物上均未观察到黏膜裂开，但在八分之七的游离移植物中存在黏膜裂开。微血管骨移植物与宿主骨在六周内实现愈合。相比之下，六周后所有动物体内的游离移植物均发生了骨坏死。两种类型移植物均出现了一个意外发现，即明显的骨膜下骨形成。这种骨似乎源自宿主床，双侧稳定并桥接缺损。结果表明，受辐射的骨膜可能在骨生成中发挥重要作用。
