Morales M J, Marx R E, Gottlieb C F
J Oral Maxillofac Surg. 1987 Jan;45(1):34-41. doi: 10.1016/0278-2391(87)90083-8.
Healing of cellular bone grafts irradiated at various times in the postsurgical course was compared to the healing characteristics of bone grafts placed into already irradiated tissue and to controls of irradiated host mandible in a rabbit model. Physical graft consolidation was assessed by load stress characteristics and serial histologic examination. Results indicated that grafts placed into already irradiated tissues failed to form bone in both phases of expected regeneration resulting in structurally weakened and histologically deficient ossicles. Bone grafts irradiated after placement were tolerant of irradiation. Bone grafts irradiated after four weeks were found to be less affected by irradiation than those irradiated within the first four weeks, forming an ossicle structurally and histologically superior to that of bone ossicles developed from grafts placed into irradiated tissues.
在兔模型中，比较了在术后不同时间照射的细胞骨移植的愈合情况，与植入已照射组织的骨移植的愈合特征以及照射的宿主下颌骨对照的愈合情况。通过负荷应力特征和系列组织学检查评估物理性移植骨融合情况。结果表明，植入已照射组织的移植骨在预期再生的两个阶段均未能形成骨，导致结构上变弱且组织学上有缺陷的小骨。植入后照射的骨移植对辐射有耐受性。发现四周后照射的骨移植比前四周内照射的骨移植受辐射影响更小，形成的小骨在结构和组织学上优于植入已照射组织的移植骨所形成的骨小体。
