Lukinmaa P L, Hietanen J, Laitinen J M, Malmström M
J Oral Maxillofac Surg. 1987 Jan;45(1):60-4. doi: 10.1016/0278-2391(87)90088-7.
Dentinoma is a rare odontogenic tumor showing the inductive effects of odontogenic epithelium on the connective tissue. A case of the tumor occurring in the region of the missing right mandibular second permanent premolar of an 11-year-old male is described. The tumor and the impacted right mandibular second deciduous molar were surgically removed. Histologically, areas of hyalinized collagen, osteodentin and tubular dentin were seen in a stroma varying from mesenchymal to more mature. Immunostaining for the distinct types I, III and IV collagens were negative in the hyalinized areas. Type IV collagen stained as a halo corresponding to the basal membrane zone surrounding the groups of odontogenic epithelial cells. Recovery was uneventful. There was no recurrence of the tumor during the first 10 months of follow-up.
牙本质瘤是一种罕见的牙源性肿瘤,显示出牙源性上皮对结缔组织的诱导作用。本文描述了一例发生在一名11岁男性缺失的右下第二恒前磨牙区域的该肿瘤病例。肿瘤与阻生的右下第二乳磨牙被手术切除。组织学上,在从间充质到更成熟的基质中可见透明化胶原、骨样牙本质和管状牙本质区域。透明化区域中针对不同类型的I、III和IV型胶原的免疫染色均为阴性。IV型胶原染色呈晕圈,对应于围绕牙源性上皮细胞群的基底膜区。恢复过程顺利。随访的前10个月内肿瘤未复发。