Kurata Y, Kushimoto H, Hoshi Y, Yutani Y, Tajima K, Yanai N, Sumita M, Horisawa Y
Jpn J Antibiot. 1986 Sep;39(9):2374-80.
One gram of cefmenoxime (CMX) was administered to each of 10 patients by a one shot intravenous injection at the beginning of surgery. At 30, 60, 90, 120 minutes after the administration, concentrations of CMX in venous blood, bone marrow blood and bone tissue were assayed by the agar-well method. CMX was smoothly transmigrated after the injection from venous blood to bone marrow blood and bone tissue, and effective concentrations higher than MIC80 values were maintained for several hours. CMX, therefore, appears to be a useful drug for the prophylaxis and the treatment of postoperative infections.
在手术开始时，对10名患者每人一次性静脉注射1克头孢甲肟（CMX）。给药后30、60、90、120分钟，采用琼脂孔法测定静脉血、骨髓血和骨组织中CMX的浓度。注射后CMX顺利地从静脉血迁移至骨髓血和骨组织，并维持高于MIC80值的有效浓度数小时。因此，CMX似乎是预防和治疗术后感染的一种有用药物。
