Nomura M, Tanaka K, Kiyomihara M, Tani N, Hasan H, Okui H, Ishikawa T, Shimosato T
Jpn J Antibiot. 1985 Nov;38(11):3111-7.
The concentration transferred to human serum and tissues in oral region after the administration of cefmenoxime (CMX) were investigated. The results were obtained as follows: The mean values of CMX-concentrations in serum at 15, 30, 60, 120 and 180 minutes after the intravenous administration of 20 ml of 5% glucose solution containing 1 g of CMX were 84.1, 52.7, 28.2, 12.7 and 8.81 micrograms/ml, respectively. The half-life times of serum concentration at T1/2 alpha and T1/2 beta were 0.55 and 1.05 hours, respectively. The mean concentrations transferred to gingiva at 15 (1 case), 30, 60 and 120 minutes after the intravenous administration of the same dose of CMX were 49.2, 14.1, 9.93 and 3.48 micrograms/g, respectively. Moreover, the ratios (tissue concentration to serum concentration) were also 67.50, 27.95, 38.46 and 32.28% at each time, respectively. CMX was administered intravenously for postoperative treatments of 13 patients, resulting in good effect from the laboratory data and clinical findings. No side effects were obtained.
研究了头孢甲肟（CMX）给药后在口腔区域转移至人血清和组织中的浓度。结果如下：静脉注射含1g CMX的20ml 5%葡萄糖溶液后15、30、60、120和180分钟时，血清中CMX浓度的平均值分别为84.1、52.7、28.2、12.7和8.81微克/毫升。血清浓度在T1/2α和T1/2β时的半衰期分别为0.55小时和1.05小时。静脉注射相同剂量的CMX后15分钟（1例）、30、60和120分钟时转移至牙龈的平均浓度分别为49.2、14.1、9.93和3.48微克/克。此外，各时间点的比值（组织浓度与血清浓度之比）分别也为67.50%、27.95%、38.46%和32.28%。对13例患者进行了静脉注射CMX术后治疗，从实验室数据和临床结果来看效果良好。未观察到副作用。
