Fujita K, Sakata H, Tanaka M, Kaeriyama M, Yoshioka H, Takimoto M, Takahashi Y
Jpn J Antibiot. 1986 Sep;39(9):2395-8.
Seven neonates and young infants were treated with cefotiam (CTM) in doses ranging from 8-25.6 mg/kg every 6 to 24 hours for 1 to 14 days, and the clinical efficacy and side effects were evaluated. Among 5 infants with bacterial infections including bacteremia, perianal abscess, pneumonia, urinary tract infection and probable sepsis and meningitis, clinical responses were excellent in 1 and good in 4 patients. In the 7 patients, no side effect attributable to CTM was observed. Serum concentrations of CTM were measured in 5 patients administered with 10 to 20 mg/kg of CTM by bolus intravenous injection. Peak serum concentrations of 21.9 to 38.0 micrograms/ml were noted in samples taken at 15 minutes after injection. Serum half-lives of the drug were 2.35 hours in 2 day-old neonate, 0.72 to 0.85 hours in 3 infants of 25 to 37 days, and 8.46 hours in an 18 day-old neonate with renal insufficiency.
对7例新生儿和婴幼儿使用头孢替安（CTM）进行治疗，剂量为每6至24小时8 - 25.6毫克/千克，疗程1至14天，并评估其临床疗效和副作用。在5例患有细菌感染（包括菌血症、肛周脓肿、肺炎、尿路感染以及可能的败血症和脑膜炎）的婴儿中，1例临床反应极佳，4例良好。在这7例患者中，未观察到归因于CTM的副作用。对5例静脉推注10至20毫克/千克CTM的患者进行了CTM血清浓度测定。注射后15分钟采集的样本中，血清峰值浓度为21.9至38.0微克/毫升。该药物的血清半衰期在2日龄新生儿中为2.35小时，在3例25至37日龄婴儿中为0.72至0.85小时，在1例患有肾功能不全的18日龄新生儿中为8.46小时。
