Iwata S, Sato Y, Kusumoto Y, Shiro H, Akita H, Nanri S, Oikawa T, Osano M, Sunakawa K
Jpn J Antibiot. 1986 Sep;39(9):2407-20.
The effect of cefotiam (CTM) on neonates and premature infants was examined in basic and clinical studies. Minimum inhibitory concentrations of CTM against 190 clinically isolated strains kept by this department were investigated. This drug was found to have a strong antibacterial effect against Escherichia coli, Klebsiella spp., Proteus mirabilis and Streptococcus agalactiae, Staphylococcus aureus and Staphylococcus epidermidis, although some strains were resistant. The CTM was given to 0-3, 4-7, and greater than or equal to 8 day-old premature infants and neonates by intravenous injection at the dose of 20 mg/kg, and we studied changes in serum CTM levels over time. Mean serum CTM levels were 62.3 micrograms/ml at 15 minutes and 16.4 micrograms/ml at 6 hours after the injection, with the half-life of 3.6 hours, for the 0-3 day-old premature infants. They were 38.5 micrograms/ml at 15 minutes and 10.1 micrograms/ml at 6 hours, with the half-life of 2.9 hours, for the 0-3 day-old neonates. Those levels were 22.5 micrograms/ml at 15 minutes and 2.9 micrograms/ml at 6 hours, with the half-life of 1.9 hours, for the 4-7 day-old neonates, and 51.8 micrograms/ml at 15 minutes and 1.0 micrograms/ml at 6 hours, with the half-life of 1.1 hours, for the greater than or equal to 8 day-old neonates. The CTM was given to 0-3 and greater than or equal to 8 day-old premature infants and neonates by 1-hour intravenous drip infusion at the dose of 20 mg/kg, and changes in serum CTM levels after the infusion were followed. The 0-3 day-old premature infant (there was only one subject) had a peak serum CTM level of 21.0 micrograms/ml 1 hour after the start of the infusion (that is, at the time of its completion), with the level decreased to 8.6 micrograms/ml at 7 hours and the half-life was 5.4 hours. The mean peak serum CTM level in 0-3 day-old neonates were 36.7 micrograms/ml at 1 hour, which decreased to a mean of 7.0 micrograms/ml at 7 hours; the half-life was 2.3 hours.(ABSTRACT TRUNCATED AT 400 WORDS)
通过基础研究和临床研究，考察了头孢替安（CTM）对新生儿和早产儿的影响。研究了CTM对本科室保存的190株临床分离菌株的最低抑菌浓度。发现该药物对大肠杆菌、克雷伯菌属、奇异变形杆菌、无乳链球菌、金黄色葡萄球菌和表皮葡萄球菌有较强的抗菌作用，尽管有些菌株耐药。对0 - 3日龄、4 - 7日龄以及大于或等于8日龄的早产儿和新生儿静脉注射20mg/kg剂量的CTM，研究血清CTM水平随时间的变化。0 - 3日龄早产儿注射后15分钟时血清CTM平均水平为62.3μg/ml，6小时时为16.4μg/ml，半衰期为3.6小时。0 - 3日龄新生儿注射后15分钟时为38.5μg/ml，6小时时为10.1μg/ml，半衰期为2.9小时。4 - 7日龄新生儿注射后15分钟时为22.5μg/ml，6小时时为2.9μg/ml，半衰期为1.9小时；大于或等于8日龄新生儿注射后15分钟时为51.8μg/ml，6小时时为1.0μg/ml，半衰期为1.1小时。对0 - 3日龄和大于或等于8日龄的早产儿和新生儿以20mg/kg剂量静脉滴注1小时给予CTM，并跟踪输注后血清CTM水平的变化。0 - 3日龄早产儿（仅1例受试者）输注开始后1小时（即输注结束时）血清CTM峰值水平为21.0μg/ml，7小时时降至8.6μg/ml，半衰期为5.4小时。0 - 3日龄新生儿的平均血清CTM峰值水平在1小时时为36.7μg/ml，7小时时降至平均7.0μg/ml；半衰期为2.3小时。（摘要截断于400字）
