Deryusheva E I, Machulin A V, Galzitskaya O V
Institute of Biological Instrumentation, Pushchino Biological Research Center, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290 Russia.
Skryabin Institute of Biochemistry and Physiology of Microorganisms, Pushchino Biological Research Center, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290 Russia.
Mol Biol (Mosk). 2021 Sep-Oct;55(5):748-771. doi: 10.31857/S0026898421050037.
The review summarizes and systematizes the data on the classification, taxonomic distribution, structural features, and functions of proteins with structural repeats. Modern approaches to the identification of structural repeats in proteins are considered. Features of specialized databases of protein domains are described. The review discusses the prospects of using repeat-containing proteins as scaffolds for drug design. The role of proteins with structural repeats in the pathogenesis of various diseases is considered. Various modern approaches to understanding the mechanisms of the evolutionary development of proteins with repeats are described and analyzed.
本综述总结并系统化了有关具有结构重复序列的蛋白质的分类、分类学分布、结构特征和功能的数据。考虑了鉴定蛋白质中结构重复序列的现代方法。描述了蛋白质结构域专门数据库的特点。本综述讨论了使用含重复序列的蛋白质作为药物设计支架的前景。考虑了具有结构重复序列的蛋白质在各种疾病发病机制中的作用。描述并分析了理解具有重复序列的蛋白质进化发展机制的各种现代方法。
