Deryusheva Evgeniya I, Machulin Andrey V, Galzitskaya Oxana V
Institute for Biological Instrumentation, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Pushchino, Russia.
Skryabin Institute of Biochemistry and Physiology of Microorganisms, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Pushchino, Russia.
Biophys Rev. 2023 Sep 7;15(5):1159-1169. doi: 10.1007/s12551-023-01130-0. eCollection 2023 Oct.
The review provides information on proteins with structural repeats, including their classification, characteristics, functions, and relevance in disease development. It explores methods for identifying structural repeats and specialized databases. The review also highlights the potential use of repeat proteins as drug design scaffolds and discusses their evolutionary mechanisms.
这篇综述提供了有关具有结构重复序列的蛋白质的信息，包括它们的分类、特征、功能以及在疾病发展中的相关性。它探讨了识别结构重复序列的方法和专门的数据库。该综述还强调了重复蛋白作为药物设计支架的潜在用途，并讨论了它们的进化机制。
