水杨酸作为一种植物激素，通过干扰类HMG的DSP1来抑制植食性昆虫的免疫反应。
Salicylic Acid, a Plant Hormone, Suppresses Phytophagous Insect Immune Response by Interrupting HMG-Like DSP1.
作者信息
Mollah Md Mahi Imam, Choi Hyong Woo, Yeam Inhwa, Lee Je Min, Kim Yonggyun
机构信息
Department of Plant Medicals, Andong National University, Andong, South Korea.
Department of Horticulture and Breeding, Andong National University, Andong, South Korea.
出版信息
Front Physiol. 2021 Oct 4;12:744272. doi: 10.3389/fphys.2021.744272. eCollection 2021.
Salicylic acid is a plant hormone that can mediate various plant physiological processes. Salicylic acid can bind to human high mobility group box 1 (HMGB1) and interrupt its role in mediating immune responses. Dorsal switch protein 1 (DSP1) is an insect homolog of HMGB1. In this study, a DSP1 () encoded in , a phytophagous insect, was characterized, and its potential role in immune response was explored. Upon bacterial challenge, Se-DSP1 was localized in the nucleus and released into the hemolymph. The released Se-DSP1 could mediate both cellular and humoral immune responses by activating eicosanoid biosynthesis. Salicylic acid could bind to Se-DSP1 with a high affinity. The immune responses of were significantly interrupted by SA feeding. Larvae reared on tomatoes with high endogenous SA levels became more susceptible to entomopathogens. Taken together, these results suggest a tritrophic defensive role of plant SA against phytophagous insects.
水杨酸是一种能介导多种植物生理过程的植物激素。水杨酸可与人高迁移率族蛋白B1（HMGB1）结合，并阻断其在介导免疫反应中的作用。背侧开关蛋白1（DSP1）是HMGB1的昆虫同源物。在本研究中，对植食性昆虫中编码的一种DSP1（）进行了表征，并探讨了其在免疫反应中的潜在作用。受到细菌攻击后，Se-DSP1定位于细胞核并释放到血淋巴中。释放的Se-DSP1可通过激活类二十烷酸生物合成来介导细胞免疫和体液免疫反应。水杨酸能以高亲和力与Se-DSP1结合。通过喂食SA可显著阻断的免疫反应。在内源SA水平高的番茄上饲养的幼虫对昆虫病原体更敏感。综上所述，这些结果表明植物SA对植食性昆虫具有三级防御作用。
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