Subadra K, S Sathasivasubramanian, Warrier S Aravind
Oral Medicine and Radiology, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Cureus. 2021 Sep 15;13(9):e18005. doi: 10.7759/cureus.18005. eCollection 2021 Sep.
Pemphigus is a chronic mucocutaneous autoimmune disease with the clinical feature of blisters that initially appear in the oral cavity and later in the skin. The dental professionals play an important role in diagnosing the disease. Early diagnosis and treatment determine the course and prognosis of the disease. Systemic corticosteroids continue to be the standard therapy for pemphigus vulgaris (PV). Management of PV involves prolonged use of steroids to control the disease and prevent relapses, but associated adverse events constantly remain a great challenge. Regular periodic clinical evaluation of patients with pemphigus on steroids is mandatory. This article describes a case of a 50-year-old woman with multiple chronic ulcers in the oral cavity in whom the diagnosis of PV was made and treated. The case study is followed by a review of the literature including etiology, pathogenesis, clinical features, as well as the various diagnostic criteria and the therapeutic options of PV.
天疱疮是一种慢性黏膜皮肤自身免疫性疾病，其临床特征为水疱，最初出现在口腔，随后出现在皮肤。牙科专业人员在该疾病的诊断中发挥着重要作用。早期诊断和治疗决定了疾病的病程和预后。全身用皮质类固醇仍然是寻常型天疱疮（PV）的标准治疗方法。PV的管理涉及长期使用类固醇来控制疾病并预防复发，但相关的不良事件仍然是一个巨大的挑战。对接受类固醇治疗的天疱疮患者进行定期临床评估是必不可少的。本文描述了一名50岁女性口腔多发慢性溃疡的病例，该患者被诊断为PV并接受了治疗。病例研究之后是对相关文献的综述，包括PV的病因、发病机制、临床特征，以及各种诊断标准和治疗选择。
