寻常性天疱疮伪装为恶性牙龈溃疡的罕见病例。
A rare case of pemphigus vulgaris disguised as a malignant gingival ulcer.
机构信息
Department of Periodontics and Oral Medicine, Xiangya Stomatological Hospital & Xiangya School of Stomatology, Hunan Key Laboratory of Oral Health Research & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxillofacial and Regenerative Medicine, Central South University, Changsha, 410008, China.
Department of Orthodontics, Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, 410008, China.
出版信息
BMC Oral Health. 2023 May 23;23(1):319. doi: 10.1186/s12903-023-02980-6.
BACKGROUND
Pemphigus vulgaris (PV) is a kind of rare and severe autoimmune bullous disease. In this case, the specificity of oral PV lies in the clinical manifestations of a single palatal ulcer, and no blisters were found in the oral mucosa. This case provides a powerful reference for dentists diagnosing and treating oral PV with atypical clinical presentations.
CASE PRESENTATION
A 54 years old female patient presented with a non-healing palatal gingival ulcer for over three months. By histopathological H&E staining and the direct immunofluorescence (DIF) test, the final diagnosis was oral PV. After topical glucocorticoid therapy, the affected area was cured.
CONCLUSIONS
In patients with prolonged erosion of the skin or oral mucosa, even if complete blisters are not visible, the physician should consider autoimmune bullous diseases and pay attention to avoid diagnostic defects.
背景
寻常型天疱疮（PV）是一种罕见且严重的自身免疫性大疱病。在本例中，口腔 PV 的特殊性在于单一的腭部溃疡的临床表现，口腔黏膜中未发现水疱。本病例为口腔科医生诊断和治疗表现不典型的口腔 PV 提供了有力的参考。
病例介绍
一名 54 岁女性患者因腭牙龈溃疡超过三个月未愈合而就诊。通过组织病理学 H&E 染色和直接免疫荧光（DIF）试验，最终诊断为口腔 PV。经局部糖皮质激素治疗后，受累区域治愈。
结论
对于皮肤或口腔黏膜持续糜烂的患者，即使完全没有水疱，医生也应考虑自身免疫性大疱病，并注意避免诊断缺陷。
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