Logothetis Constantine N, Konstantinov Nikifor K, Reyes Michael D, Emil N Suzanne, Tzamaloukas Antonios H
Internal Medicine, University of South Florida, Tampa, USA.
Dermatology, University of Minnesota School of Medicine, Minneapolis, USA.
Cureus. 2021 Sep 17;13(9):e18064. doi: 10.7759/cureus.18064. eCollection 2021 Sep.
A man with systemic sclerosis (SS), manifested by characteristic skin lesions, gastro-esophageal reflux disease, and pulmonary fibrosis producing progressive respiratory failure, and a positive antinuclear antibody consistent with reactivity to fibrillarin, developed skin lesions with the clinical and histological characteristics of lupus erythematosus tumidus (LET) 10 years after the diagnosis of SS. His respiratory failure progressed and he expired from sepsis after tracheal intubation and mechanical ventilation two years after developing LET. The association of SS and LET, not described until now, raises questions about its pathogenesis and its prognostic significance.
一名患有系统性硬化症（SS）的男性，表现为特征性皮肤病变、胃食管反流病以及导致进行性呼吸衰竭的肺纤维化，抗核抗体呈阳性且与对核仁纤维蛋白的反应性一致。在诊断为SS 10年后，他出现了具有肿胀性红斑狼疮（LET）临床和组织学特征的皮肤病变。他的呼吸衰竭不断进展，在出现LET两年后，气管插管和机械通气后因败血症死亡。SS与LET的关联此前未被描述，这引发了关于其发病机制及其预后意义的问题。
