接种SARS-CoV-2 mRNA疫苗后格雷夫斯病（一种Th1型细胞因子疾病）复发：纯属巧合？
Recurrence of Graves' Disease (a Th1-type Cytokine Disease) Following SARS-CoV-2 mRNA Vaccine Administration: A Simple Coincidence?
作者信息
Pierman Guillaume, Delgrange Etienne, Jonas Corinne
机构信息
Department of Endocrinology, Centre Hospitalier Universitaire de Mont-Godinne, Yvoir, Belgium.
出版信息
Eur J Case Rep Intern Med. 2021 Sep 2;8(9):002807. doi: 10.12890/2021_002807. eCollection 2021.
UNLABELLED
Graves' disease is the most frequent cause of hyperthyroidism in young women. This auto-immune disease is due to the production of class 1 IgG stimulating the TSH receptor. These antibodies are produced secondary to a Th1 immune response in which interferon gamma plays a key role. Vaccination is ongoing worldwide against SARS-CoV-2 and some of the vaccines include mRNA which seems to stimulate the Th1 immune response. Here, we report a case of recurrence of hyperthyroidism due to Graves' disease following mRNA vaccination and discuss the possible implicated mechanism. This observation argues for a systematic study of a population of patients with previous Graves' disease in order to assess the risk of recurrence following vaccination.
LEARNING POINTS
Graves' disease is a Th1-mediated immune disease in which interferon gamma plays a key role.The recurrence of hyperthyroidism due to Grave's disease should be monitored in patients exposed to risk factors.
未标注
格雷夫斯病是年轻女性甲状腺功能亢进最常见的病因。这种自身免疫性疾病是由于产生了刺激促甲状腺激素受体的1类IgG。这些抗体继发于Th1免疫反应产生，其中γ干扰素起关键作用。全球正在进行针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的疫苗接种，一些疫苗包含信使核糖核酸（mRNA），其似乎能刺激Th1免疫反应。在此，我们报告1例mRNA疫苗接种后格雷夫斯病导致甲状腺功能亢进复发的病例，并讨论可能涉及的机制。这一观察结果支持对既往患有格雷夫斯病的患者群体进行系统研究，以评估疫苗接种后复发的风险。
学习要点
格雷夫斯病是一种Th1介导的免疫疾病，其中γ干扰素起关键作用。对于暴露于风险因素的患者，应监测格雷夫斯病所致甲状腺功能亢进的复发情况。
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