Department of Internal Medicine and Dialysis Center, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina.
Psychiatr Danub. 2021 Sep;33(Suppl 10):58-62.
Association of Helicobacter pylori (HP) infection with the length of dialysis in dialysis patients is contradictory. This study was conducted in order to determine the association between the duration of dialysis and the HP infection status in the dialysis patients. Furthemore, biochemical parameters were monitored in two subject groups that were included in this study.
The study included 51 patients on chronic hemodialysis program who had gastrointestinal symptoms. The subjects were divided in two groups per the length of dialysis treatment. In this study we analyzed age, gender, the time period since the onset of the chronic hemodialysis program, body mass index, biochemical parameters, and whether the patients have arterial hypertension and/or diabetes. The presence of HP antigen was determined in the stool samples with use of he UlcoGnost AG test plate.
The incidence of HP infection in hemodialysis patients, with some of the gastrointestinal symptoms, was 25.5%. Patients on hemodialysis for less than 24 months had lower incidence of HP infection than those on hemodialysis program for more than 24 months. HP positive and HP negative subjects were also compared by gender, age, biochemical parameters and body mass index. There was no statistical significant difference between the groups in any of those characteristics. When comparing the HP status of the subjects with the presence of arterial hypertension and diabetes, no statistically significant difference was found between the groups.
This study showed negative correlation between HP infection and the length of hemodialysis program. Analysis of age, gender, body mass index, biochemical parameters, presence of arterial hypertension and/or diabetes showed no statistically significant difference was found between the hemodialysis patients who were HP positive and those who were HP negative. Additional studies are needed to elucidate the correlation mechanism between the HP infection and the duration of dialysis, in order to examine how long the dialysis time period is the most susceptible to HP infection, and then to improve the prognosis of patients with renal disease.
幽门螺杆菌（HP）感染与透析患者透析时间的关系存在争议。本研究旨在确定透析患者的透析时间与 HP 感染状况之间的关系。此外，我们监测了纳入本研究的两个研究组的生化参数。
本研究纳入了 51 名有胃肠道症状的慢性血液透析患者。根据透析治疗时间的长短，将患者分为两组。在本研究中，我们分析了年龄、性别、慢性血液透析计划开始后的时间、体重指数、生化参数以及患者是否患有动脉高血压和/或糖尿病。使用 UlcoGnost AG 测试板检测粪便样本中的 HP 抗原。
有胃肠道症状的血液透析患者中，HP 感染的发生率为 25.5%。透析时间少于 24 个月的患者的 HP 感染发生率低于透析时间超过 24 个月的患者。我们还比较了 HP 阳性和 HP 阴性患者的性别、年龄、生化参数和体重指数。在这些特征中，两组之间没有统计学上的显著差异。当比较受试者的 HP 状态与动脉高血压和糖尿病的存在时，两组之间没有发现统计学上的显著差异。
本研究显示 HP 感染与血液透析方案的长度呈负相关。对年龄、性别、体重指数、生化参数、动脉高血压和/或糖尿病的分析显示，HP 阳性和 HP 阴性患者之间没有统计学上的显著差异。需要进一步的研究来阐明 HP 感染与透析时间之间的相关机制，以检查透析时间多久最容易感染 HP，然后改善肾病患者的预后。
