Department of Pediatrics, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
Department of Neonatology, and Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
J Interferon Cytokine Res. 2021 Oct;41(10):365-374. doi: 10.1089/jir.2021.0094.
Infection is the leading cause of admission and mortality in neonatal intensive care units. Immature immune function and antibiotic resistance make the treatment more difficult. However, there is no effective prevention for it. Recently, more and more researches are focusing on stem cell therapy, especially mesenchymal stem cells (MSCs); their potential paracrine effect confer MSCs with a major advantage to treat the immune and inflammatory disorders associated with neonatal infection. In this review, we summarize the basal properties and preclinical evidence of MSCs and explore the potential mechanisms of paracrine factors of MSCs for neonatal infection.
感染是新生儿重症监护病房（NICU）患儿住院和死亡的主要原因。新生儿免疫功能不成熟和抗生素耐药使治疗更加困难。然而，目前还没有有效的预防措施。最近，越来越多的研究集中在干细胞治疗上，特别是间充质干细胞（MSCs）；它们潜在的旁分泌作用使 MSCs 具有治疗与新生儿感染相关的免疫和炎症紊乱的主要优势。在这篇综述中，我们总结了 MSCs 的基本特性和临床前证据，并探讨了 MSCs 旁分泌因子治疗新生儿感染的潜在机制。
