Regenerative Processing Plant, LLC, 34176 US Highway 19 N Palm Harbor, Palm Harbor, FL 34684, USA.
Institute of Anatomy, University of Bern, Baltzerstrasse 2, 3012 Bern, Switzerland.
Int J Mol Sci. 2021 Mar 1;22(5):2472. doi: 10.3390/ijms22052472.
Mesenchymal stem cells (MSCs) are self-renewable, rapidly proliferating, multipotent stem cells which reside in almost all post-natal tissues. MSCs possess potent immunoregulatory properties and, in juxtacrine and paracrine manner, modulate phenotype and function of all immune cells that participate in tissue repair and regeneration. Additionally, MSCs produce various pro-angiogenic factors and promote neo-vascularization in healing tissues, contributing to their enhanced repair and regeneration. In this review article, we summarized current knowledge about molecular mechanisms that regulate the crosstalk between MSCs and immune cells in tissue repair and regeneration.
间充质干细胞（MSCs）是自我更新、快速增殖、多能干细胞，存在于几乎所有的出生后组织中。MSCs 具有强大的免疫调节特性，并以旁分泌和自分泌的方式调节参与组织修复和再生的所有免疫细胞的表型和功能。此外，MSCs 产生各种促血管生成因子，并促进愈合组织中的新血管生成，有助于增强其修复和再生能力。在这篇综述文章中，我们总结了目前关于调节 MSCs 与免疫细胞在组织修复和再生中相互作用的分子机制的知识。
