Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Department of Breast Surgery, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Ear Nose Throat J. 2024 May;103(5):NP278-NP288. doi: 10.1177/01455613211048970. Epub 2021 Oct 21.
Laryngeal squamous cell carcinoma (LSCC) is a common squamous cell carcinoma of the head and neck with no reliable diagnostic biomarkers. However, recent studies have shown that inflammation plays an essential role in tumor development, and several inflammation-based biomarkers have been shown to have prognostic value. This study aimed to investigate the auxiliary value of fibrinogen (FIB), fibrinogen degradation products (FDP), and lymphocyte/monocyte ratio (LMR) in LSCC diagnosis and prognosis.
Clinical data from 218 patients recently diagnosed with LSCC and 207 diagnosed with benign laryngeal lesions (BLLs) were retrospectively reviewed. Potential diagnostic biomarkers were evaluated using univariate and multivariate analyses; receiver operating characteristic (ROC) curve analysis was used to identify cut-off values and diagnostic efficiency. Least absolute shrinkage and selection operator (LASSO) Logistic regression analysis was used to screen for independent risk factors to construct a diagnostic nomogram. The chi-squared test and Kaplan-Meier method were performed to investigate the correlation of clinicopathological characteristics and 3-year overall survival (OS) with FIB, FDP, and LMR in patients with LSCC.
FIB, FDP, and LMR levels were significantly different between the LSCC and BLL groups ( < .001), and all were independent risk factors for LSCC. The area under the ROC curve of the diagnostic nomogram was .894. Additionally, FIB, FDP, and LMR were correlated with some invasive clinicopathological features, and LMR ≥4.29 was associated with reduced OS ( = .038).
FIB, FDP, and LMR demonstrated potential as biomarkers for the diagnosis and prognosis of LSCC; however, further studies are needed to confirm their efficacy.
喉鳞状细胞癌（LSCC）是头颈部常见的鳞状细胞癌，目前尚无可靠的诊断生物标志物。然而，最近的研究表明，炎症在肿瘤发展中起着重要作用，并且已经证明几种基于炎症的生物标志物具有预后价值。本研究旨在探讨纤维蛋白原（FIB）、纤维蛋白原降解产物（FDP）和淋巴细胞/单核细胞比值（LMR）在 LSCC 诊断和预后中的辅助价值。
回顾性分析了 218 例最近诊断为 LSCC 的患者和 207 例诊断为良性喉病变（BLL）的患者的临床资料。采用单因素和多因素分析评估潜在的诊断生物标志物；采用受试者工作特征（ROC）曲线分析确定截断值和诊断效率。采用最小绝对值收缩和选择算子（LASSO）Logistic 回归分析筛选独立危险因素，构建诊断列线图。采用卡方检验和 Kaplan-Meier 法探讨 FIB、FDP 和 LMR 与 LSCC 患者临床病理特征及 3 年总生存（OS）的相关性。
LSCC 组和 BLL 组的 FIB、FDP 和 LMR 水平差异均有统计学意义（ <.001），均为 LSCC 的独立危险因素。诊断列线图的 ROC 曲线下面积为 0.894。此外，FIB、FDP 和 LMR 与某些侵袭性临床病理特征相关，LMR≥4.29 与 OS 降低相关（ =.038）。
FIB、FDP 和 LMR 具有作为 LSCC 诊断和预后生物标志物的潜力；然而，需要进一步的研究来证实其疗效。
