Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Laboratory of Veterinary Parasitology, Faculty of Agriculture, Iwate University, Morioka, Japan.
J Vet Diagn Invest. 2021 Nov;33(6):1137-1141. doi: 10.1177/10406387211033583.
Neuroleptospirosis is a rare disease caused by pathogenic in humans; however, it has not been fully studied in animals. A young wild raccoon dog was found convulsing in the recumbent position and died the next day. Histologic examination revealed nonsuppurative meningoencephalitis in the cerebrum, cerebellum, midbrain, and medulla oblongata. The lesions consisted of mixed infiltrates of Iba1-positive macrophages and CD3-positive T cells, with a small number of CD79α-positive B cells and myeloperoxidase-positive neutrophils. In the frontal cortex, perivascular cuffs and adjacent microglial nodules were distributed diffusely, especially in the molecular layer. Glial nodules were comprised of Iba1- and myeloperoxidase-positive activated microglia. Immunohistochemistry revealed leptospires in mononuclear cell perivascular cuffs, but not in glial nodules. Neuroleptospirosis was accompanied by -related nonsuppurative interstitial nephritis, pulmonary edema and hemorrhage, and coronary periarteritis, as well as in the small intestine and nonspecific foreign-body granulomas in the lungs and stomach.
神经莱姆螺旋体病是一种由致病性螺旋体引起的罕见疾病，在动物中尚未得到充分研究。一只年轻的野生貉犬被发现仰卧抽搐，并于次日死亡。组织学检查显示大脑、小脑、中脑和延髓存在非化脓性脑膜脑炎。病变由 Iba1 阳性巨噬细胞和 CD3 阳性 T 细胞混合浸润组成，伴有少量 CD79α 阳性 B 细胞和髓过氧化物酶阳性中性粒细胞。在额皮质中，血管周围袖套和相邻的小胶质细胞结节呈弥漫性分布，特别是在分子层。神经胶质结节由 Iba1 和髓过氧化物酶阳性的活化小胶质细胞组成。免疫组化显示单核细胞血管周围袖套中有螺旋体，但神经胶质结节中没有。神经莱姆螺旋体病伴有与相关的非化脓性间质性肾炎、肺水肿和出血，以及冠状动脉周围炎，以及小肠和肺、胃中的非特异性异物性肉芽肿。
