Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, 210009, Jiangsu, China.
Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, 210009, Jiangsu, China.
Environ Pollut. 2022 Jan 1;292(Pt B):118387. doi: 10.1016/j.envpol.2021.118387. Epub 2021 Oct 19.
Ambient particulate air pollution is a risk factor for cardiovascular and respiratory disease, yet the biological mechanisms underlying this association are not well understood. The current study aimed to investigate the mediation role of microRNAs on the association between personal PM exposure and blood pressure and lung function. One hundred and twenty adults (60 truck drivers and 60 office workers) aged 18-46 years were assessed on the June 15, 2008 and at follow-up (1- to 2-weeks later). MicroRNAs were extracted from the peripheral blood samples. Compared to truck drivers, there is a significant increase in FEF, FEV, and FEV/FVC and a decrease in PM in office workers (all p < 0.05). According to the Bonferroni corrected threshold p-value < 6.81 × 10 (0.05/734) used, personal PM data showed a significant positive association with miR-644 after the adjustment for age, BMI, smoking status, and habitual alcohol use. The mediation effect of miR-644 on the association between personal PM exposure and FEF [B (95%CI) = -1.342 (-2.810, -0.113)], PEF [B (95%CI) = -1.793 (-3.926, -0.195)], and FEV/FVC [B (95%CI) = -0.119‰ (-0.224‰, -0.026‰)] was significant only for truck drivers after the adjustment for covariates. There were no similar associations with blood pressure. These results demonstrate microRNAs to potentially mediate association of PM with lung function. Subsequent studies are needed to further elucidate the potential mechanisms of action by which the mediation effect of microRNAs is achieved with this process.
环境细颗粒物空气污染是心血管和呼吸道疾病的风险因素，但这种关联的生物学机制尚不清楚。本研究旨在探讨 microRNAs 在个体 PM 暴露与血压和肺功能之间的关联中的中介作用。120 名年龄在 18-46 岁的成年人（60 名卡车司机和 60 名办公室工作人员）于 2008 年 6 月 15 日和随访（1-2 周后）进行评估。从外周血样中提取 microRNAs。与卡车司机相比，办公室工作人员的 FEF、FEV 和 FEV/FVC 显著增加，PM 显著降低（均 P<0.05）。根据 Bonferroni 校正后的阈值 p 值<6.81×10（0.05/734），个人 PM 数据在调整年龄、BMI、吸烟状况和习惯性饮酒后与 miR-644 呈显著正相关。miR-644 在个人 PM 暴露与 FEF [B（95%CI）=-1.342（-2.810，-0.113）]、PEF [B（95%CI）=-1.793（-3.926，-0.195）]和 FEV/FVC [B（95%CI）=-0.119‰（-0.224‰，-0.026‰）]之间的关联具有显著的中介作用，仅在调整协变量后对卡车司机而言。与血压无类似关联。这些结果表明 microRNAs 可能介导 PM 与肺功能的关联。需要进一步的研究来进一步阐明 microRNAs 中介作用实现这一过程的潜在作用机制。
