Xu Ning, Cong Xiaowei, Sun Rongli, Yin Lihong, Zhang Juan, Pu Yuepu
Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu 210009, China.
The Jiangsu Province Official Hospital, Nanjing, Jiangsu 210009, China.
Prev Med Rep. 2023 Jul 5;35:102314. doi: 10.1016/j.pmedr.2023.102314. eCollection 2023 Oct.
Colorectal cancer is the second leading cause of global cancer-related deaths, and its precursor lesions are colorectal polyps (CAP). The study aimed to explore the effect of combinations of unhealthy lifestyles on CAP and investigate the mediation role of metabolic disorder in this process. A total of 1299 adults were recruited from a hospital in Jiangsu, China, including 811 cases and 488 adults without diseases. The information on demographic characteristics and lifestyles was collected through questionnaires and the medical record system. Serum biochemical parameters were determined using the automatic biochemical analyzer. Adjusted regression analysis showed that unhealthy lifestyles, including smoking, overnight meals, daily water intake, staying up late, and exercise associated with the risk of CAP. Furthermore, metabolic biomarkers, including BMI, triglycerides, and uric acid, were associated with the risk of CAP. Also, unhealthy lifestyle scores were positively associated with BMI, triglycerides, and CAP. The mediation effect of metabolic biomarkers, such as BMI and triglycerides on the association of unhealthy lifestyle scores with CAP was significant. Available data demonstrate the adverse effect of combinations of unhealthy lifestyle factors on CAP, and metabolic disorders to potentially mediate the association of unhealthy lifestyles with the risk of CAP.
结直肠癌是全球癌症相关死亡的第二大主要原因，其癌前病变是结直肠息肉（CAP）。本研究旨在探讨不健康生活方式组合对CAP的影响，并研究代谢紊乱在此过程中的中介作用。在中国江苏的一家医院共招募了1299名成年人，其中包括811例病例和488名无疾病的成年人。通过问卷调查和病历系统收集人口统计学特征和生活方式信息。使用自动生化分析仪测定血清生化参数。调整后的回归分析表明，不健康的生活方式，包括吸烟、吃夜宵、每日饮水量、熬夜和运动与CAP风险相关。此外，代谢生物标志物，包括体重指数（BMI）、甘油三酯和尿酸，与CAP风险相关。而且，不健康生活方式得分与BMI、甘油三酯和CAP呈正相关。BMI和甘油三酯等代谢生物标志物对不健康生活方式得分与CAP关联的中介作用显著。现有数据表明不健康生活方式因素组合对CAP有不良影响，且代谢紊乱可能介导不健康生活方式与CAP风险的关联。
