Cognitive Neuroimaging Unit, INSERM, CEA, CNRS, Université Paris-Saclay, NeuroSpin center, Gif/Yvette, France.
Cognitive Neuroimaging Unit, INSERM, CEA, CNRS, Université Paris-Saclay, NeuroSpin center, Gif/Yvette, France; Collège de France, Université PSL Paris Sciences Lettres, Paris, France.
Cortex. 2021 Dec;145:13-36. doi: 10.1016/j.cortex.2021.09.003. Epub 2021 Oct 14.
The ability to detect the abstract pattern underlying a temporal sequence of events is crucial to many human activities, including language and mathematics, but its cortical correlates remain poorly understood. It is also unclear whether repeated exposure to the same sequence of sensory stimuli is sufficient to induce the encoding of an abstract amodal representation of the pattern. Using functional MRI, we probed the existence of such abstract codes for sequential patterns, their localization in the human brain, and their relation to existing language and math-responsive networks. We used a passive sequence violation paradigm, in which a given sequence is repeatedly presented before rare deviant sequences are introduced. We presented two binary patterns, AABB and ABAB, in four presentation formats, either visual or auditory, and either cued by the identity of the stimuli or by their spatial location. Regardless of the presentation format, a habituation to the repeated pattern and a response to pattern violations were seen in a set of inferior frontal, intraparietal and temporal areas. Within language areas, such pattern-violation responses were only found in the inferior frontal gyrus (IFG), whereas all math-responsive regions responded to pattern changes. Most of these regions also responded whenever the modality or the cue changed, suggesting a general sensitivity to violation detection. Thus, the representation of sequence patterns appears to be distributed, yet to include a core set of abstract amodal regions, particularly the IFG.
检测事件时间序列下潜在抽象模式的能力对许多人类活动至关重要，包括语言和数学，但皮质相关区域仍知之甚少。目前也不清楚重复暴露于相同的感官刺激序列是否足以诱导模式的抽象无模态表示的编码。我们使用功能磁共振成像技术，探究了顺序模式的这种抽象代码是否存在，其在人脑内的定位，以及它们与现有语言和数学反应网络的关系。我们使用被动序列违规范式，在该范式中，在引入罕见的异常序列之前，重复呈现给定的序列。我们呈现了两种二进制模式，AABB 和 ABAB，以四种呈现格式，无论是视觉还是听觉，无论是通过刺激的身份还是通过它们的空间位置来提示。无论呈现格式如何，在一系列额下回、顶内回和颞叶区域都可以看到对重复模式的习惯化和对模式违规的反应。在语言区域内，只有在额下回（IFG）中才能发现对模式违规的反应，而所有对数学有反应的区域都对模式变化有反应。这些区域中的大多数在模态或提示发生变化时也会做出反应，这表明它们对违规检测具有普遍的敏感性。因此，序列模式的表示似乎是分布式的，但包括一组核心的抽象无模态区域，特别是 IFG。
