University of Minnesota.
University of Arizona.
Oncol Nurs Forum. 2021 Nov 1;48(6):623-633. doi: 10.1188/21.ONF.623-633.
To explore the relationship between biomarkers of oxidative stress and inflmmation in cerebrospinal fluid (CSF) and cognitive function in children receiving maintenance therapy for acute lymphocytic leukemia (ALL).
SAMPLE & SETTING: 30 participants aged 4-17 years receiving ALL maintenance therapy at two pediatric cancer centers in the United States.
METHODS & VARIABLES: F2-isoprostane (F2-ISoP) and interleukin-8 (IL-8) were evaluated in CSF samples, and cognitive function measures were completed during the first and last cycles of ALL maintenance. The Flanker Inhibitory Control and Attention Test (Flanker) and Dimensional Change Card Sort were completed during the last cycle.
During maintenance therapy, IL-8 decreased, and parent reports of children's cognitive function improved. Higher IL-8 was associated with better parent reports of children's cognitive function at each timepoint. Higher F2-ISoP levels were associated with lower Flanker scores.
F2-ISoP may be a useful biomarker in evaluating cognitive dysfunction in children with ALL and merits further investigation.
探讨接受急性淋巴细胞白血病（ALL）维持治疗的儿童脑脊液（CSF）中氧化应激和炎症生物标志物与认知功能的关系。
在美国两家儿科癌症中心接受 ALL 维持治疗的 30 名 4-17 岁的参与者。
在 CSF 样本中评估 F2-异前列腺素（F2-ISoP）和白细胞介素-8（IL-8），并在 ALL 维持的第一个和最后一个周期完成认知功能测量。在最后一个周期完成 Flanker 抑制控制和注意力测试（Flanker）和维度变化卡片分类。
在维持治疗期间，IL-8 下降，家长报告儿童的认知功能改善。较高的 IL-8 与每个时间点家长报告的儿童认知功能较好相关。较高的 F2-ISoP 水平与 Flanker 评分较低相关。
F2-ISoP 可能是评估 ALL 儿童认知功能障碍的有用生物标志物，值得进一步研究。
