Fujimoto Y, Yabuno T, Kato M, Nishioka K, Fujita T
Res Commun Chem Pathol Pharmacol. 1986 Oct;54(1):115-9.
Effects of methylmercuric chloride (MMC) in the absence and presence of ascorbic acid on the synthesis of prostaglandins E2 and F2 alpha, and the lipid peroxidation of rabbit kidney medulla slices were studied. MMC showed dose-dependent inhibition of prostaglandins E2 and F2 alpha formation. The lipid peroxidation was not stimulated by MMC alone. Ascorbic acid plus MMC were able to stimulate the lipid peroxidation markedly, but the lipid peroxidation induced by ascorbic acid plus MMC had no influence on prostaglandin E2 production decreased by MMC alone. These results suggest that MMC inhibits prostaglandin formation by affecting the activity of prostaglandin cyclooxygenase, but that lipid peroxidation is not directly responsible for this inhibitory effect of MMC.
研究了在不存在和存在抗坏血酸的情况下，氯化甲基汞（MMC）对兔肾髓质切片中前列腺素E2和F2α合成以及脂质过氧化的影响。MMC对前列腺素E2和F2α的形成表现出剂量依赖性抑制作用。单独的MMC不会刺激脂质过氧化。抗坏血酸加MMC能够显著刺激脂质过氧化，但抗坏血酸加MMC诱导的脂质过氧化对单独MMC降低的前列腺素E2生成没有影响。这些结果表明，MMC通过影响前列腺素环氧化酶的活性来抑制前列腺素的形成，但脂质过氧化并非MMC这种抑制作用的直接原因。
