兔肾髓质切片中脂质过氧化与前列腺素合成之间的相互作用。
The interaction between lipid peroxidation and prostaglandin synthesis in rabbit kidney-medulla slices.
作者信息
Fujimoto Y, Tanioka H, Keshi I, Fujita T
出版信息
Biochem J. 1983 Apr 15;212(1):167-71. doi: 10.1042/bj2120167.
Abstract
Lipid peroxidation induced by ascorbic acid and Fe2+ was inhibited by mepacrine (phospholipase A2 inhibitor) and aspirin (prostaglandin cyclo-oxygenase inhibitor) in rabbit kidney-medulla slices. Moreover, ascorbic acid and Fe2+ potentiated the inhibitory effect on prostaglandin E2 formation by mepacrine, but they had no influence on prostaglandin E2 production decreased by aspirin. Lipid peroxidation induced by ascorbic acid and Fe2+ appears to be affecting the activity of prostaglandin endoperoxide synthase. These results suggest that lipid peroxidation is connected closely with the prostaglandin-generating system, and it has the potential to modulate the turnover of arachidonic acid and prostaglandin synthesis.
摘要
在兔肾髓质切片中，阿的平（磷脂酶A2抑制剂）和阿司匹林（前列腺素环氧化酶抑制剂）可抑制由抗坏血酸和Fe2+诱导的脂质过氧化。此外，抗坏血酸和Fe2+增强了阿的平对前列腺素E2形成的抑制作用，但它们对阿司匹林降低的前列腺素E2生成没有影响。由抗坏血酸和Fe2+诱导的脂质过氧化似乎影响了前列腺素内过氧化物合酶的活性。这些结果表明，脂质过氧化与前列腺素生成系统密切相关，并且它有可能调节花生四烯酸的周转和前列腺素的合成。
相似文献
1
The interaction between lipid peroxidation and prostaglandin synthesis in rabbit kidney-medulla slices.兔肾髓质切片中脂质过氧化与前列腺素合成之间的相互作用。
Biochem J. 1983 Apr 15;212(1):167-71. doi: 10.1042/bj2120167.
2
Comparison of the effects of Fe2+ and Cu2+ on prostaglandin synthesis in rabbit kidney medulla slices.
J Pharm Pharmacol. 1987 Mar;39(3):230-3. doi: 10.1111/j.2042-7158.1987.tb06256.x.
3
Effect of methyl mercury on prostaglandin synthesis in rabbit kidney medulla slices.甲基汞对兔肾髓质切片中前列腺素合成的影响。
Res Commun Chem Pathol Pharmacol. 1986 Oct;54(1):115-9.
4
Stimulation of prostaglandin E2 synthesis by exogenous phospholipase A2 and C in rabbit kidney medulla slices.外源性磷脂酶A2和C对兔肾髓质切片中前列腺素E2合成的刺激作用。
Biochem J. 1984 Feb 15;218(1):69-74. doi: 10.1042/bj2180069.
5
Inhibition of prostaglandin synthesis in rabbit kidney medulla slices by antioxidants.抗氧化剂对兔肾髓质切片中前列腺素合成的抑制作用。
J Pharm Pharmacol. 1984 Mar;36(3):195-7. doi: 10.1111/j.2042-7158.1984.tb06939.x.
6
Effect of diarachidonin on prostaglandin E2 synthesis in rabbit kidney medulla slices.二花生四烯酸甘油酯对兔肾髓质切片中前列腺素E2合成的影响。
Biochem J. 1985 Dec 15;232(3):625-8. doi: 10.1042/bj2320625.
7
Effects of lipid peroxidation on prostaglandin synthesis in rabbit kidney medulla slices.脂质过氧化对兔肾髓质切片中前列腺素合成的影响。
Biochim Biophys Acta. 1982 Jan 15;710(1):82-6.
8
Prostaglandin biosynthesis in rabbit kidney: mepacrine inhibits renomedullary cyclooxygenase.兔肾中的前列腺素生物合成：米帕林抑制肾髓质环氧化酶。
Biochem Pharmacol. 1984 Jan 1;33(1):79-82. doi: 10.1016/0006-2952(84)90372-1.
9
Triacylglycerol lipase-mediated release of arachidonic acid for renal medullary prostaglandin synthesis.三酰甘油脂肪酶介导花生四烯酸的释放以用于肾髓质前列腺素的合成。
Arch Biochem Biophys. 1988 Mar;261(2):368-74. doi: 10.1016/0003-9861(88)90352-9.
10
Effects of lipid peroxidation, Ca2+ and adrenalin on the release of fatty acids from rabbit kidney cortex slices.
Biochim Biophys Acta. 1982 Dec 13;713(3):688-91.
引用本文的文献
1
Protective effect of quinacrine against glycerol-induced acute kidney injury in rats.喹吖因对甘油诱导的大鼠急性肾损伤的保护作用。
BMC Nephrol. 2017 Jan 28;18(1):41. doi: 10.1186/s12882-017-0450-8.
2
Stimulation of prostaglandin E2 synthesis by exogenous phospholipase A2 and C in rabbit kidney medulla slices.外源性磷脂酶A2和C对兔肾髓质切片中前列腺素E2合成的刺激作用。
Biochem J. 1984 Feb 15;218(1):69-74. doi: 10.1042/bj2180069.
3
Uptake of secondary autoxidation products of linoleic acid by the rat.大鼠对亚油酸二次自氧化产物的摄取
Lipids. 1985 Jul;20(7):412-9. doi: 10.1007/BF02534231.
4
Effect of diarachidonin on prostaglandin E2 synthesis in rabbit kidney medulla slices.二花生四烯酸甘油酯对兔肾髓质切片中前列腺素E2合成的影响。
Biochem J. 1985 Dec 15;232(3):625-8. doi: 10.1042/bj2320625.
5
Effect of angiotensin-converting enzyme inhibitor YS980 on prostaglandin synthesis in rabbit kidney medulla slices.血管紧张素转换酶抑制剂YS980对兔肾髓质切片中前列腺素合成的影响。
Br J Pharmacol. 1987 Nov;92(3):479-81. doi: 10.1111/j.1476-5381.1987.tb11346.x.
本文引用的文献
1
PROSTAGLANDINS AND RELATED FACTORS: XIX. THIN-LAYER CHROMATOGRAPHY OF PROSTAGLANDINS.前列腺素及相关因子：十九。前列腺素的薄层色谱法。
J Lipid Res. 1964 Jan;5:117-20.
2
Inhibition of oxidative hemolysis and lipid peroxidation by mepacrine.米帕林对氧化溶血和脂质过氧化的抑制作用。
J Biochem. 1981 Apr;89(4):1143-8.
3
Effects of 4-pentenoic acid and furosemide on renal functions and renal uptake of individual free fatty acids.4-戊烯酸和呋塞米对肾功能及各游离脂肪酸肾摄取的影响。
Pflugers Arch. 1980 May;385(2):111-6. doi: 10.1007/BF00588689.
4
Effects of lipid peroxidation on prostaglandin synthesis in rabbit kidney medulla slices.脂质过氧化对兔肾髓质切片中前列腺素合成的影响。
Biochim Biophys Acta. 1982 Jan 15;710(1):82-6.
5
Inactivation of ribonuclease and other enzymes by peroxidizing lipids and by malonaldehyde.通过过氧化脂质和丙二醛使核糖核酸酶及其他酶失活。
Biochemistry. 1969 Jul;8(7):2827-32. doi: 10.1021/bi00835a020.
6
A sensitive method for the determination of prostaglandins by gas chromatography with electron-capture detection.一种采用电子捕获检测气相色谱法测定前列腺素的灵敏方法。
Biochim Biophys Acta. 1970 Feb 10;202(1):231-4. doi: 10.1016/0005-2760(70)90246-8.
7
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.抑制前列腺素合成作为阿司匹林类药物的作用机制。
Nat New Biol. 1971 Jun 23;231(25):232-5. doi: 10.1038/newbio231232a0.
8
Quantitative and qualitative analyses of isolated lipid droplets from interstitial cells in renal papillae from various species.对来自不同物种肾乳头间质细胞中分离出的脂滴进行定量和定性分析。
Lipids. 1974 Nov;9(11):835-43. doi: 10.1007/BF02532606.
9
Lipid peroxidation damage to cell components.脂质过氧化对细胞成分的损害。
Fed Proc. 1973 Aug;32(8):1870-4.
10
Prostaglandin synthetase system--resolution into oxygenase and isomerase components.前列腺素合成酶系统——分解为加氧酶和异构酶成分。
Proc Natl Acad Sci U S A. 1974 Sep;71(9):3645-8. doi: 10.1073/pnas.71.9.3645.
Zotero 插件