Fujimoto Y, Tanioka H, Keshi I, Fujita T
Biochem J. 1983 Apr 15;212(1):167-71. doi: 10.1042/bj2120167.
Lipid peroxidation induced by ascorbic acid and Fe2+ was inhibited by mepacrine (phospholipase A2 inhibitor) and aspirin (prostaglandin cyclo-oxygenase inhibitor) in rabbit kidney-medulla slices. Moreover, ascorbic acid and Fe2+ potentiated the inhibitory effect on prostaglandin E2 formation by mepacrine, but they had no influence on prostaglandin E2 production decreased by aspirin. Lipid peroxidation induced by ascorbic acid and Fe2+ appears to be affecting the activity of prostaglandin endoperoxide synthase. These results suggest that lipid peroxidation is connected closely with the prostaglandin-generating system, and it has the potential to modulate the turnover of arachidonic acid and prostaglandin synthesis.
在兔肾髓质切片中，阿的平（磷脂酶A2抑制剂）和阿司匹林（前列腺素环氧化酶抑制剂）可抑制由抗坏血酸和Fe2+诱导的脂质过氧化。此外，抗坏血酸和Fe2+增强了阿的平对前列腺素E2形成的抑制作用，但它们对阿司匹林降低的前列腺素E2生成没有影响。由抗坏血酸和Fe2+诱导的脂质过氧化似乎影响了前列腺素内过氧化物合酶的活性。这些结果表明，脂质过氧化与前列腺素生成系统密切相关，并且它有可能调节花生四烯酸的周转和前列腺素的合成。
