Auriol M, Diner P, Degois G, Boisnic S, Chomette G
Rev Stomatol Chir Maxillofac. 1986;87(5):276-81.
One case of Merkel cell carcinoma is reported in a 71 years-old woman. Lately treated by surgical excision (14 years after the occurrence of the tumour), this tumour was already associated with inguinal lymph node metastases. Its evolution was lethal within 3 months after local recurrence, cutaneous and visceral (lung, liver) metastases. This tumour, characteristic histologically and ultrastructurally (secretory granules), was accompanied by an infiltrative epidermoid carcinoma. This association and the presence of cytokeratin in tumoral Merkel cells are arguments for the common origin of keratinocytes and neuroendocrine Merkel cells from a common young epithelial cell.
报告了一例71岁女性的默克尔细胞癌。该肿瘤最近接受了手术切除(肿瘤发生14年后),当时已伴有腹股沟淋巴结转移。在局部复发、皮肤和内脏(肺、肝)转移后3个月内,病情进展至致命。该肿瘤在组织学和超微结构上具有特征性(分泌颗粒),同时伴有浸润性表皮样癌。这种关联以及肿瘤性默克尔细胞中细胞角蛋白的存在支持了角质形成细胞和神经内分泌默克尔细胞起源于共同的年轻上皮细胞这一观点。