Wätzig V, Katenkamp D
Z Hautkr. 1987 Jul 15;62(14):1105-12.
Two nearly identical cases with about 100 multicentric disseminated neuroendocrine carcinomas of the skin are presented. In the Merkel cell tumors a for epithelial cells specific antigen (MAM-6) was found by immunohistochemical methods. Only in one patient generalized metastases arose after a four year course of the disease. The other patient committed suicide after a three year course of the disease. At autopsy no metastases were seen. We assume these diseases to be a systemic proliferation of malignant neuroendocrine differentiated epithelial cells, for which the term "cutaneous Merkeliomatosis" is proposed.
本文报告了两例几乎相同的病例，均患有约100处多中心播散性皮肤神经内分泌癌。在默克尔细胞瘤中，通过免疫组织化学方法发现了一种上皮细胞特异性抗原（MAM-6）。只有一名患者在病程四年后出现了全身转移。另一名患者在病程三年后自杀。尸检未发现转移。我们认为这些疾病是恶性神经内分泌分化上皮细胞的全身性增殖，为此提出了“皮肤默克尔细胞瘤病”这一术语。
