人附睾蛋白 4：缺血性心肌病的新型预测因子。
Human epididymis protein 4: a novel predictor of ischemic cardiomyopathy.
机构信息
Department of Cardiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Normal University, Changsha, 410005, China.
Department of Gastroenterology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Hunan Normal University, Changsha, 410005, China.
出版信息
BMC Cardiovasc Disord. 2021 Oct 21;21(1):511. doi: 10.1186/s12872-021-02319-5.
BACKGROUND
The prognostic value of human epididymis protein 4 (HE4) in patients with ischemic cardiomyopathy (ICM) is unknown.
METHODS
A total of 103 patients with ICM were prospectively enrolled in this study from Hunan Provincial People's Hospital between February 2019 and June 2019. All patients were tested for HE4 levels at baseline and follow-up. Endpoints of the study included cardiovascular death and heart failure-related hospitalization.
RESULTS
A total of 96 patients with ICM were included for analysis. After a mean follow-up period of 263 (153-313) days, cardiovascular events were observed in 45 patients. Serum HE4 levels in patients with events were significantly higher than those in patients without events [188.70 (113.35-326.82) pmol/L versus 92.90 (61.50-123.20) pmol/L, P < 0.001]. Multivariate Cox regression analysis revealed that HE4 [χ: 9.602, hazard ratio (HR): 1.003, 95% confidence interval (CI): 1.001-1.005, P = 0.002] and age [χ: 4.55, HR: 1.044, 95% CI: 1.003-1.085, P = 0.033] were independent predictors of events. After adjusting for age and sex, the risk of events in patients with HE4 > 100.2 pmol/L was higher than that in patients with HE4 ≤ 100.2 pmol/L [HR: 3.372, 95% CI: 1.409-8.065, P < 0.001].
CONCLUSION
HE4 is an independent predictor of cardiovascular death and heart failure-related rehospitalization in patients with ICM.
背景
人附睾蛋白 4（HE4）在缺血性心肌病（ICM）患者中的预后价值尚不清楚。
方法
本研究前瞻性纳入 2019 年 2 月至 2019 年 6 月湖南省人民医院的 103 例 ICM 患者。所有患者在基线和随访时均检测 HE4 水平。研究终点包括心血管死亡和心力衰竭相关住院。
结果
共纳入 96 例 ICM 患者进行分析。平均随访 263（153-313）天后，45 例患者发生心血管事件。有事件的患者血清 HE4 水平明显高于无事件的患者[188.70（113.35-326.82）pmol/L 比 92.90（61.50-123.20）pmol/L，P<0.001]。多变量 Cox 回归分析显示，HE4[χ：9.602，风险比（HR）：1.003，95%置信区间（CI）：1.001-1.005，P=0.002]和年龄[χ：4.55，HR：1.044，95%CI：1.003-1.085，P=0.033]是事件的独立预测因子。在校正年龄和性别后，HE4>100.2 pmol/L 的患者发生事件的风险高于 HE4≤100.2 pmol/L 的患者[HR：3.372，95%CI：1.409-8.065，P<0.001]。
结论
HE4 是 ICM 患者心血管死亡和心力衰竭相关再住院的独立预测因子。
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