人附睾蛋白4水平与射血分数保留的心力衰竭患者的不良预后相关。
The level of human epididymis protein 4 is associated with poor prognosis in patients with ejection fraction preserved heart failure.
作者信息
Tang Yi, Chen Yu, Huang Xiao Jiao, Hu Zheng Qi, Hu Yon Jun, Peng Si-Ling, Pan Hong-Wei
机构信息
Department of Cardiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Normal University, Changsha, China.
Department of Cardiology, The First Affiliated Hospital of Hunan Normal University Hunan Provincial People's Hospital, Hunan Normal University, Changsha, China.
出版信息
Front Cardiovasc Med. 2025 Aug 18;12:1530271. doi: 10.3389/fcvm.2025.1530271. eCollection 2025.
INTRODUCTION
The prognostic value of human epididymis protein 4 (HE4) in patients with heart failure with preserved ejection fraction (HFpEF) is unknown.
METHODS
Patients diagnosed with HFpEF in the Department of Cardiovascular Medicine of Hunan Provincial People's Hospital from January 2021 to August 2022 were prospectively enrolled in the study. Serum levels of HE4 were measured using a chemiluminescence microparticle immunoassay. Endpoint events included readmission for heart failure and cardiovascular death.
RESULTS
A total of 170 patients with HFpEF were included in the study; among them, 86 (50.6%) were male, with a mean age of 68.9 ± 0.8 years. A total of 71 patients experienced endpoint events, including 67 patients with rehospitalizations for heart failure and 4 patients with cardiovascular deaths, with an average follow-up of 18.0 ± 0.8 months. Multivariate Cox regression analysis revealed that HE4 was an independent predictor of endpoint events (HR = 1.009, 95% CI 1.002-1.015, = 0.010). The Kaplan-Meier survival curves revealed that the risk of endpoint events was significantly higher in patients with HE4 > 42.45 pmol/L than in those with HE4 ≤ 42.45 pmol/L (HR = 2.66, 95% CI 1.37-5.17, < 0.01). After adjusting for age and gender, the HR was 2.48 (95% CI 1.21-5.08, < 0.05).
CONCLUSION
HE4 is an independent predictor of heart failure rehospitalization and cardiovascular death in patients with HFpEF.
引言
人附睾蛋白4（HE4）在射血分数保留的心力衰竭（HFpEF）患者中的预后价值尚不清楚。
方法
前瞻性纳入2021年1月至2022年8月在湖南省人民医院心血管内科诊断为HFpEF的患者。采用化学发光微粒子免疫分析法测定血清HE4水平。终点事件包括因心力衰竭再次入院和心血管死亡。
结果
本研究共纳入170例HFpEF患者；其中男性86例（50.6%），平均年龄68.9±0.8岁。共有71例患者发生终点事件，包括67例因心力衰竭再次住院和4例心血管死亡，平均随访18.0±0.8个月。多因素Cox回归分析显示，HE4是终点事件的独立预测因子（HR=1.009，95%CI 1.002-1.015，P=0.010）。Kaplan-Meier生存曲线显示，HE4>42.45 pmol/L的患者发生终点事件的风险显著高于HE4≤42.45 pmol/L的患者（HR=2.66，95%CI 1.37-5.17，P<0.0）。在调整年龄和性别后，HR为2.48（95%CI 1.21-5.08，P<0.05）。
结论
HE4是HFpEF患者心力衰竭再住院和心血管死亡的独立预测因子。
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