Taub Institute, Columbia University Irving Medical Center, New York, NY, USA.
Taub Institute, Columbia University Irving Medical Center, New York, NY, USA.
Trends Neurosci. 2021 Dec;44(12):927-929. doi: 10.1016/j.tins.2021.10.002. Epub 2021 Oct 18.
Autopsy and imaging studies have demonstrated a typical pattern of tau progression in Alzheimer's disease (AD), spreading to previously unaffected regions in an anatomical sequence of 'Braak' stages. In a recent study, Pascoal et al. provide evidence that microgliosis colocalizes with tau in a Braak-like pattern, furthering the notion that microglial activation is strongly related to the propagation of tangle pathology.
尸检和影像学研究表明，阿尔茨海默病（AD）中 tau 的进展具有典型模式，按照“Braak”阶段的解剖顺序传播到以前未受影响的区域。在最近的一项研究中，Pascoal 等人提供了证据表明小胶质细胞与 tau 以类似 Braak 的模式共定位，进一步表明小胶质细胞的激活与缠结病理的传播密切相关。
