Sleep and Circadian Neurobiology Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA.
Department of Psychiatry and Behavioral Science, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Sci Rep. 2021 Oct 21;11(1):20816. doi: 10.1038/s41598-021-00271-0.
Sleep deprivation induces adverse effects on the health, productivity, and performance. The individuals who could not get enough sleep temporarily experience the symptoms of an induced acute insomnia. This study investigated the efficacy of sake yeast in treatment of acute insomnia in mice. The results of this study showed that sake yeast induced a significant dose-dependent wake reduction, a rapid eye movement (REM) and a non-REM (NREM) sleep enhancement during the first 6 h after the oral administration of sake yeast with locomotor activity and core body temperature decreases under the stressful environment in a new cage. In fact, the wake amounts at 3 h and 6 h were significantly reduced after the oral administration of sake yeast compared with the vehicle. The NREM sleep amounts at 3 h and 6 h significantly increased after the administration of sake yeast compared with the vehicle. The REM amount at 6 h significantly increased after the administration of sake yeast compared with the vehicle, but not at 3 h. The previous study suggested that the sleep-promoting effects of sake yeast could be referred from the activating effect of adenosine A receptor (AR). In summary, the sake yeast is an AR agonist and may induce sleep due to its stress-reducing and anti-anxiety properties. Further verification of the involvement of adenosine in the pathophysiology of insomnia is needed.
睡眠剥夺会对健康、生产力和表现产生不利影响。那些无法获得足够睡眠的人会暂时经历诱导性急性失眠的症状。本研究调查了清酒酵母治疗小鼠急性失眠的疗效。研究结果表明，清酒酵母在口服清酒酵母后 6 小时内，可显著剂量依赖性地减少清醒时间，增强快速眼动（REM）和非快速眼动（NREM）睡眠，同时降低运动活性和核心体温，在新笼中处于应激环境下。事实上，与载体相比，口服清酒酵母后 3 小时和 6 小时的清醒量显著减少。与载体相比，口服清酒酵母后 3 小时和 6 小时的 NREM 睡眠时间显著增加。与载体相比，口服清酒酵母后 6 小时的 REM 睡眠时间显著增加，但 3 小时时没有增加。先前的研究表明，清酒酵母的促眠作用可能与其激活腺苷 A 受体（AR）的作用有关。综上所述，清酒酵母是一种 AR 激动剂，可能因其具有减轻压力和抗焦虑的特性而诱导睡眠。需要进一步验证腺苷在失眠病理生理学中的作用。
