腺苷与P1受体：睡眠、蛰伏和冬眠调节中的关键靶点。
Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation.
作者信息
Ma Wei-Xiang, Yuan Ping-Chuan, Zhang Hui, Kong Ling-Xi, Lazarus Michael, Qu Wei-Min, Wang Yi-Qun, Huang Zhi-Li
机构信息
State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Department of Pharmacology, School of Basic Medical Sciences, Institutes of Brain Science, Fudan University, Shanghai, China.
Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, China.
出版信息
Front Pharmacol. 2023 Mar 10;14:1098976. doi: 10.3389/fphar.2023.1098976. eCollection 2023.
Sleep, torpor, and hibernation are three distinct hypometabolic states. However, they have some similar physiological features, such as decreased core body temperature and slowing heart rate. In addition, the accumulation of adenosine seems to be a common feature before entry into these three states, suggesting that adenosine and its receptors, also known as P1 receptors, may mediate the initiation and maintenance of these states. This review, therefore, summarizes the current research on the roles and possible neurobiological mechanisms of adenosine and P1 receptors in sleep, torpor, and hibernation. Understanding these aspects will give us better prospects in sleep disorders, therapeutic hypothermia, and aerospace medicine.
睡眠、蛰伏和冬眠是三种不同的低代谢状态。然而，它们具有一些相似的生理特征，如核心体温降低和心率减缓。此外，腺苷的积累似乎是进入这三种状态之前的一个共同特征，这表明腺苷及其受体（也称为P1受体）可能介导这些状态的起始和维持。因此，本综述总结了目前关于腺苷和P1受体在睡眠、蛰伏和冬眠中的作用及可能的神经生物学机制的研究。了解这些方面将为我们在睡眠障碍、治疗性低温和航空航天医学方面带来更好的前景。
Zotero 插件