Rekha Umapathy Vidhya, Anita M, Bhuminathan S, Sadhana K
Department of Public Health Dentistry, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai 600 100, India.
Department of Prosthodontics, Sree Balaji Dental College and Hospital, BIHER, Pallikaranai, Chennai 600 100, India.
Bioinformation. 2020 Oct 31;16(10):742-747. doi: 10.6026/97320630016742. eCollection 2020.
Janus kinase 2 (JAK2) is a tyrosine kinase receptor that belongs to the JAK family kinases is linked to oral cancer. We describe the molecular binding analysis of JAK2 with 23 compounds from tomotoes. Docking data shows five compounds (rutin, qucertin, narigenin, chlrogenia acid & kaempferol) with optimal binding features with JAK2 for further consideration.
Janus激酶2（JAK2）是一种酪氨酸激酶受体，属于JAK家族激酶，与口腔癌有关。我们描述了JAK2与来自番茄的23种化合物的分子结合分析。对接数据显示有5种化合物（芦丁、槲皮素、柚皮素、绿原酸和山奈酚）与JAK2具有最佳结合特征，值得进一步研究。
