长链非编码RNA Linc01315的过表达预示乳腺癌预后不良。
Overexpression of Long Non-Coding RNA Linc01315 Predicts Poor Prognosis in Breast Cancer.
作者信息
Xue Jingyan, Huang Sheng, Chen Jiaying, Chen Yi-Zuo, Shao Zhi-Min, Wu Jiong, Chi Yayun
机构信息
Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
出版信息
Front Oncol. 2021 Oct 5;11:562378. doi: 10.3389/fonc.2021.562378. eCollection 2021.
BACKGROUND
LncRNAs have been shown to play critical roles in regulating tumorigenesis and tumor progression. Using LncRNAs to predict prognosis and therapeutic response to cancer treatment has been caused for concern, but the predictive value of lncRNAs remains to be explored and underlying mechanisms have not been completely understood.
METHODS
The Linc01315 expression level was detected in 282 breast cancer tissues by using quantitative RT-PCR. The association between Linc01315 expression level and clinicopathological features of these breast cancer patients was further analyzed. Multiple regression analysis was used to evaluate Linc01315 predictive value of patients' prognosis.
RESULTS
Our study revealed that Linc01315 expression level was significantly correlated with vessel invasion ( = 0.028) and tumor subtype ( = 0.039). The Kaplan-Meier survival curves demonstrated that patients with lower Linc01315 expression level had significantly longer disease free survival (DFS) ( = 0.002) and overall survival (OS) (=0.019). Multiple regression analysis showed that Linc01315 level could be an independent predictive factor for DFS (hazards ratio = 0.613, 95% confidence interval = 0.375-1.003; = 0.049) and OS (hazards ratio = 0.439, 95% confidence interval = 0.228-0.845; = 0.014). Further analysis showed that low Linc01315 level patients with endocrine therapy could benefit patients DFS (=0.037) and OS (=0.025).
CONCLUSION
Our results demonstrate that Linc01315 expression level is significantly correlated with breast cancer patients' prognosis. Linc01315 may represent an independent prognostic marker and therapeutic target in breast cancer.
背景
长链非编码RNA（LncRNAs）已被证明在调节肿瘤发生和肿瘤进展中起关键作用。利用LncRNAs预测癌症治疗的预后和治疗反应已引起关注，但LncRNAs的预测价值仍有待探索，其潜在机制尚未完全明确。
方法
采用定量逆转录聚合酶链反应（qRT-PCR）检测282例乳腺癌组织中Linc01315的表达水平。进一步分析Linc01315表达水平与这些乳腺癌患者临床病理特征之间的关联。采用多元回归分析评估Linc01315对患者预后的预测价值。
结果
我们的研究表明，Linc01315表达水平与血管侵犯（P = 0.028）和肿瘤亚型（P = 0.039）显著相关。Kaplan-Meier生存曲线显示，Linc01315表达水平较低的患者无病生存期（DFS）显著延长（P = 0.002），总生存期（OS）也显著延长（P = 0.019）。多元回归分析表明，Linc01315水平可能是DFS（风险比 = 0.613，95%置信区间 = 0.375 - 1.003；P = 0.049）和OS（风险比 = 0.439，95%置信区间 = 0.228 - 0.845；P = 0.014）的独立预测因素。进一步分析表明，Linc01315水平低的患者接受内分泌治疗可使DFS（P = 0.037）和OS（P = 0.025）获益。
结论
我们的结果表明，Linc01315表达水平与乳腺癌患者的预后显著相关。Linc01315可能是乳腺癌的一个独立预后标志物和治疗靶点。
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