Linc00959的高表达预示着乳腺癌的预后不良。
High expression of Linc00959 predicts poor prognosis in breast cancer.
作者信息
Chi Weiru, Huang Sheng, Xiu Bingqiu, Zhang Qi, Shao Zhiming, Wu Jiong, Chi Yayun
机构信息
1Department of Breast Surgery, Breast Cancer Institute, Fudan University Shanghai Cancer Center, Building 7, No. 270 Dong An Road, Shanghai, 200032 China.
2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
出版信息
Cancer Cell Int. 2019 Feb 20;19:39. doi: 10.1186/s12935-019-0748-7. eCollection 2019.
BACKGROUND
Accumulating studies have focused on the oncogenic roles of the newly identified lncRNAs in human cancers. The aim of this study was to examine the expression pattern of Linc00959 in BC and to evaluate its biological role and clinical significance in prediction of prognosis.
METHODS
Expression of Linc00959 was detected in 290 BC tissues by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). We analyzed the relationship between Linc00959 expression and clinic pathological features of BC patients. The correlation was calculated by SPSS software.
RESULTS
Our results revealed that Linc00959 expression was correlated with ER status (p = 0.005), PR status (p = 0.036), Ki67 (p = 0.025) and HER2 status (p = 0.009). The Kaplan-Meier survival curves indicated that the overall survival (OS) (p = 0.022) and relapse-free survival (RFS) (p = 0.002) were significantly poor in high Linc00959 expression BC patients (p = 0.023). Furthermore, the survival analysis by Cox regression showed that Linc00959 served as an independent prognostic marker in breast cancer (p = 0.004).
CONCLUSION
Our studies indicate that Linc00959 is significantly associated with poor prognosis and may represent a new marker of prognosis in breast cancer.
背景
越来越多的研究聚焦于新发现的长链非编码RNA（lncRNAs）在人类癌症中的致癌作用。本研究旨在检测Linc00959在乳腺癌（BC）中的表达模式，并评估其在预测预后方面的生物学作用和临床意义。
方法
采用定量逆转录聚合酶链反应（qRT-PCR）检测290例BC组织中Linc00959的表达。分析Linc00959表达与BC患者临床病理特征之间的关系。相关性通过SPSS软件计算。
结果
我们的结果显示，Linc00959表达与雌激素受体（ER）状态（p = 0.005）、孕激素受体（PR）状态（p = 0.036）、Ki67（p = 0.025）和人表皮生长因子受体2（HER2）状态（p = 0.009）相关。Kaplan-Meier生存曲线表明，Linc00959高表达的BC患者总生存期（OS）（p = 0.022）和无复发生存期（RFS）（p = 0.002）显著较差（p = 0.023）。此外，Cox回归生存分析显示，Linc00959是乳腺癌的独立预后标志物（p = 0.004）。
结论
我们的研究表明，Linc00959与不良预后显著相关，可能代表乳腺癌预后的一个新标志物。
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