miR-100-5p是一种新型生物标志物，可抑制皮肤黑色素瘤的增殖、迁移和侵袭。
miR-100-5p Is a Novel Biomarker That Suppresses the Proliferation, Migration, and Invasion in Skin Cutaneous Melanoma.
作者信息
Zhang Xiao, Deng Yuqi, Liang Xiao, Rao Yamin, Zheng Haiyan, Liu Fei, Luo Xusong, Yang Jun, Chen Jun, Sun Di
机构信息
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Department of Pathology, Shanghai Ninth People's Hospital, Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200011, China.
出版信息
Stem Cells Int. 2022 Sep 20;2022:3585540. doi: 10.1155/2022/3585540. eCollection 2022.
OBJECTIVE
To better understand the role and underlying mechanisms of SKCM, we conducted bioinformatics analysis and in vivo experiments.
RESULTS
We found its role as a tumor suppressor gene in SKCM and its effect on prognosis. In addition, this study found that miR-100-5p had a bidirectional effect on SKCM microenvironment. After exploring the relationship between the two, it was found that tumors with intermediate miR-100-5p expression had the highest level of immune cell infiltration. In addition, the value of miR-100-5p was assessed by survival analysis, univariate Cox regression analysis, and nomogram prognostic prediction. Finally, we constructed a regulatory network to illustrate the regulatory relationship of miR-100-5p.
CONCLUSIONS
In conclusion, the antitumor effect of miR-100-5p is revealed, and the present study is followed by a discussion of its molecular regulatory network, followed by novel insights into SKCM therapy.
目的
为了更好地理解皮肤黑色素瘤（SKCM）的作用及潜在机制，我们进行了生物信息学分析和体内实验。
结果
我们发现了其在SKCM中作为肿瘤抑制基因的作用及其对预后的影响。此外，本研究发现miR-100-5p对SKCM微环境具有双向作用。在探究两者之间的关系后，发现miR-100-5p表达处于中等水平的肿瘤免疫细胞浸润水平最高。此外，通过生存分析、单因素Cox回归分析和列线图预后预测评估了miR-100-5p的价值。最后，我们构建了一个调控网络来说明miR-100-5p的调控关系。
结论
总之，揭示了miR-100-5p的抗肿瘤作用，本研究随后讨论了其分子调控网络，为SKCM治疗提供了新的见解。
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