School of Life, Health & Chemical Sciences, The Open University, Milton Keynes, MK7 6AA, UK.
Division of Cellular & Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, CB2 0QQ, UK.
Epigenomics. 2021 Nov;13(22):1831-1843. doi: 10.2217/epi-2021-0069. Epub 2021 Oct 22.
Long noncoding RNAs (lncRNAs) have a wide range of functions in health and disease, but many remain uncharacterized because of their complex expression patterns and structures. The genetic loci encoding lncRNAs can be subject to accelerated evolutionary changes within the human lineage. is a region that has a significantly altered sequence compared to other primates and is a component of two overlapping lncRNA loci, and . Although the functions of these lncRNAs are unknown, they have been associated with neurological disorders and cancer. Here, we explore the current state of understanding of evolution in human lncRNA genes, using the locus as the case study.
长链非编码 RNA（lncRNA）在健康和疾病中有广泛的功能，但由于其复杂的表达模式和结构，许多 lncRNA 仍未被阐明。编码 lncRNA 的遗传基因座可能在人类谱系内经历加速进化变化。内含子 1 是一个与其他灵长类动物相比序列显著改变的区域，是两个重叠的 lncRNA 基因座 和 的组成部分。尽管这些 lncRNA 的功能未知，但它们与神经退行性疾病和癌症有关。在这里，我们以内含子 1 基因座为例，探讨人类 lncRNA 基因进化的现有理解状态。
