Ni Yu-Qing, Xu Hui, Liu You-Shuo
Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha, China.
Institute of Aging and Age-Related Disease Research, Central South University, Changsha, China.
Front Mol Neurosci. 2022 Mar 14;15:844193. doi: 10.3389/fnmol.2022.844193. eCollection 2022.
Aging-related neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), are gradually becoming the primary burden of society and cause significant health-care concerns. Aging is a critical independent risk factor for neurodegenerative diseases. The pathological alterations of neurodegenerative diseases are tightly associated with mitochondrial dysfunction, inflammation, and oxidative stress, which in turn stimulates the further progression of neurodegenerative diseases. Given the potential research value, lncRNAs have attracted considerable attention. LncRNAs play complex and dynamic roles in multiple signal transduction axis of neurodegeneration. Emerging evidence indicates that lncRNAs exert crucial regulatory effects in the initiation and development of aging-related neurodegenerative diseases. This review compiles the underlying pathological mechanisms of aging and related neurodegenerative diseases. Besides, we discuss the roles of lncRNAs in aging. In addition, the crosstalk and network of lncRNAs in neurodegenerative diseases are also explored.
与衰老相关的神经退行性疾病，包括阿尔茨海默病（AD）、帕金森病（PD）、亨廷顿病（HD）和肌萎缩侧索硬化症（ALS），正逐渐成为社会的主要负担，并引发了重大的医疗保健问题。衰老是神经退行性疾病的一个关键独立危险因素。神经退行性疾病的病理改变与线粒体功能障碍、炎症和氧化应激密切相关，而这反过来又会刺激神经退行性疾病的进一步发展。鉴于其潜在的研究价值，长链非编码RNA（lncRNAs）已引起了相当大的关注。lncRNAs在神经退行性变的多个信号转导轴中发挥着复杂而动态的作用。新出现的证据表明，lncRNAs在与衰老相关的神经退行性疾病的发生和发展中发挥着关键的调节作用。本综述汇编了衰老及相关神经退行性疾病的潜在病理机制。此外，我们还讨论了lncRNAs在衰老中的作用。此外，还探讨了lncRNAs在神经退行性疾病中的相互作用和网络。
