CD20、CD200、CD43和CD45在慢性淋巴细胞白血病中的独立诊断效用
Independent diagnostic utility of CD20, CD200, CD43 and CD45 in chronic lymphocytic leukaemia.
作者信息
Ramalingam Thulasi Raman, Mohanraj Selvaraj, Muthu Anurekha, Prabhakar Vikram, Ramakrishnan Balasubramaniam, Vaidhyanathan Lakshman, Easow Jose, Raja Thirumalairaj
机构信息
Department of Hematology, Apollo Cancer Centre, Chennai, India.
Department of Biostatistics, Apollo Hospital, Chennai, India.
出版信息
Leuk Lymphoma. 2022 Feb;63(2):377-384. doi: 10.1080/10428194.2021.1992621. Epub 2021 Oct 22.
Immunophenotyping plays a major role and is essential for establishing the diagnosis of chronic lymphocytic leukemia (CLL). Though CLL has a characteristic phenotype, diagnosis may be challenging due to immunophenotypic overlap with other B cell non-Hodgkin's lymphomas (B-NHL). Markers like CD200, CD43, CD20 and CD45 were found valuable in CLL and we investigated their diagnostic efficiency and accuracy in 174 patients with leukemic B-NHL. On the integration of four markers by a scoring system, 96% (49/51) of CLL cases showed a score of 3 or 4 and 90% (36/40) of non-CLL cases had a score of 0 or 1. This scoring system for CLL diagnosis showed a sensitivity of 98.2% and 96% in the analytical cohort and validation cohort respectively, which was significantly higher than the classical Matutes score. Hence we strongly suggest considering the expression of CD200, CD20, CD43 and CD45 in the diagnosis of B-NHL cases.
免疫表型分析在慢性淋巴细胞白血病（CLL）的诊断中起着重要作用且至关重要。尽管CLL具有特征性表型，但由于其与其他B细胞非霍奇金淋巴瘤（B-NHL）存在免疫表型重叠，诊断可能具有挑战性。发现CD200、CD43、CD20和CD45等标志物在CLL中具有重要价值，我们对174例白血病性B-NHL患者研究了它们的诊断效率和准确性。通过评分系统整合这四种标志物时，96%（49/51）的CLL病例评分为3或4，90%（36/40）的非CLL病例评分为0或1。这种用于CLL诊断的评分系统在分析队列和验证队列中的敏感性分别为98.2%和96%，显著高于经典的马图特评分。因此，我们强烈建议在B-NHL病例的诊断中考虑CD200、CD20、CD43和CD45的表达。
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