由六亚甲基双乙酰胺脱乙酰作用产生的分解代谢产物在小鼠红白血病细胞分化中起关键作用。
Catabolites produced by the deacetylation of hexamethylenebisacetamide play a key role in murine erythroleukaemic-cell differentiation.
作者信息
Meilhoc E, Moutin M J, Osborne H B
出版信息
Biochem J. 1986 Sep 15;238(3):701-7. doi: 10.1042/bj2380701.
Abstract
N-Acetyl-1,6-diaminohexane and 1,6-diaminohexane, formed by deacetylation of the inducer hexamethylenebisacetamide (HMBA), are shown to accumulate rapidly inside murine erythroleukaemic cells. The appearance of these molecules preceded the differentiation-associated changes in intracellular polyamines. A quantitative relationship was observed between the accumulation of these molecules and the changes in intracellular polyamines. In the absence of HMBA, exogenous N-acetyl-1,6-diaminohexane was able not only to cause changes in polyamine biosynthesis, but also to induce the complete differentiation process. These results imply that these catabolites of HMBA are directly responsible for the changes in polyamine biosynthesis and probably also for initiating other events regulatory for the differentiation of these cells.
摘要
诱导剂六亚甲基双乙酰胺（HMBA）脱乙酰化形成的N-乙酰基-1,6-二氨基己烷和1,6-二氨基己烷，被证明能在小鼠红白血病细胞内迅速积累。这些分子的出现先于细胞内多胺与分化相关的变化。观察到这些分子的积累与细胞内多胺的变化之间存在定量关系。在没有HMBA的情况下，外源性N-乙酰基-1,6-二氨基己烷不仅能够引起多胺生物合成的变化，还能诱导完全分化过程。这些结果表明，HMBA的这些分解代谢产物直接导致了多胺生物合成的变化，并且可能还引发了对这些细胞分化起调节作用的其他事件。
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