Mehta Ashish, Lu Peter, Taylor Bruce V, Charlesworth Jac, Cook Anthony L, Burdon Kathryn P, Hewitt Alex W, Young Kaylene M
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, Australia.
Stem Cell Res. 2021 Dec;57:102568. doi: 10.1016/j.scr.2021.102568. Epub 2021 Oct 12.
Multiple sclerosis (MS) is a chronic autoimmune and neurodegenerative disease that results in immune cell infiltration of the central nervous system (CNS) and demyelination in young adults. Substantial progress has been made in developing disease modifying therapies for people with relapsing-remitting MS, but options remain limited for people with primary progressive MS (PPMS). PPMS accounts for ∼15% of MS diagnoses. Herein, we generated a human induced pluripotent stem cell line (hiPSC) from a person with clinically definite PPMS. This disease-specific hiPSC line will be useful for studying PPMS in vitro, allowing the generation of immune and CNS cell types.
多发性硬化症（MS）是一种慢性自身免疫性神经退行性疾病，会导致免疫细胞浸润中枢神经系统（CNS）并在年轻人中引发脱髓鞘。在为复发缓解型MS患者开发疾病修正疗法方面已取得了重大进展，但对于原发性进展型MS（PPMS）患者而言，治疗选择仍然有限。PPMS约占MS诊断病例的15%。在此，我们从一名临床确诊为PPMS的患者身上生成了一种人诱导多能干细胞系（hiPSC）。这种疾病特异性hiPSC系将有助于在体外研究PPMS，从而能够生成免疫细胞和CNS细胞类型。
