青霉胺对大鼠骨肉瘤细胞毒性的研究。

Studies on the cytotoxicity of penicillamine in a rat osteogenic sarcoma.

作者信息

Cosolo W, Christophidis N, Drummer O H, Findlay D M

出版信息

Clin Exp Pharmacol Physiol. 1986 Oct;13(10):737-43. doi: 10.1111/j.1440-1681.1986.tb02415.x.

DOI:10.1111/j.1440-1681.1986.tb02415.x

Abstract

The effect of penicillamine on the growth rate of an osteogenic sarcoma of rats was investigated and compared with cyclophosphamide. Rats were inoculated with a readily transplantable osteogenic sarcoma subcutaneously into the left thigh and treated with penicillamine and cyclophosphamide alone or in combination. Cyclophosphamide inhibited tumour growth. Penicillamine did not delay the appearance or the growth rate of the tumour. Tumour sizes tended to be larger in the penicillamine-treated rats, but there was no evidence that penicillamine interfered with the antitumour effect of cyclophosphamide given in large doses (100 mg/kg).

摘要

研究了青霉胺对大鼠骨肉瘤生长速率的影响，并与环磷酰胺进行比较。将大鼠左大腿皮下接种易移植的骨肉瘤，单独或联合使用青霉胺和环磷酰胺进行治疗。环磷酰胺抑制肿瘤生长。青霉胺未延缓肿瘤的出现或生长速率。接受青霉胺治疗的大鼠肿瘤大小往往更大，但没有证据表明青霉胺会干扰大剂量（100mg/kg）环磷酰胺的抗肿瘤作用。