末端脱氧核苷酸转移酶基因位于人类第10号染色体（10q23----q24）和小鼠第19号染色体上。

The terminal deoxynucleotidyltransferase gene is located on human chromosome 10 (10q23----q24) and on mouse chromosome 19.

作者信息

Yang-Feng T L, Landau N R, Baltimore D, Francke U

出版信息

Cytogenet Cell Genet. 1986;43(3-4):121-6. doi: 10.1159/000132309.

Abstract

Terminal deoxynucleotidyltransferase (TdT) is a DNA polymerase expressed in immature lymphocytes of the thymus and bone marrow, as well as certain leukemic cells. Chromosomal assignment of the gene coding for human TdT was accomplished by in situ hybridization of a 3H-labeled cDNA probe to human chromosome preparations and by Southern blot analysis of somatic cell hybrid DNAs. The human TdT gene was mapped to the region q23----q24 of chromosome 10. Breaks at this site have been reported in different translocations in human leukemias. The mouse TdT gene was assigned to chromosome 19 by Southern blot analysis of mouse X Chinese hamster somatic cell hybrids. This result adds a fourth locus to the conserved syntenic group on mouse chromosome 19 and human chromosome 10.

摘要

末端脱氧核苷酸转移酶（TdT）是一种在胸腺和骨髓的未成熟淋巴细胞以及某些白血病细胞中表达的DNA聚合酶。通过将3H标记的cDNA探针与人类染色体标本进行原位杂交以及对体细胞杂种DNA进行Southern印迹分析，完成了编码人类TdT的基因的染色体定位。人类TdT基因被定位于10号染色体的q23----q24区域。在人类白血病的不同易位中已报道了该位点的断裂。通过对小鼠X中国仓鼠体细胞杂种进行Southern印迹分析，将小鼠TdT基因定位于19号染色体。这一结果为小鼠19号染色体和人类10号染色体上保守的同线群增加了第四个基因座。