将羧肽酶A基因定位于人类染色体7q22----qter以及小鼠染色体6。

Assignment of the gene for carboxypeptidase A to human chromosome 7q22----qter and to mouse chromosome 6.

作者信息

Honey N K, Sakaguchi A Y, Lalley P A, Quinto C, Rutter W J, Naylor S L

出版信息

Hum Genet. 1986 Jan;72(1):27-31. doi: 10.1007/BF00278813.

Abstract

A rat cDNA probe for preprocarboxypeptidase A was used to follow the segregation of the human gene for carboxypeptidase A (CPA) in 49 human X mouse somatic cell hybrids using Southern filter hybridization techniques. CPA was assigned to human chromosome 7q22----qter. Similarly, the probe was used to follow the segregation of the mouse gene for carboxypeptidase A (Cpa) in 19 mouse X Chinese hamster somatic cell hybrids. Cpa was assigned to mouse chromosome 6. The gene for carboxypeptidase A forms part of a syntenic group that is conserved in man and mouse.

摘要

利用Southern印迹杂交技术，用大鼠前羧肽酶A的cDNA探针追踪49个人-小鼠体细胞杂种中人类羧肽酶A（CPA）基因的分离情况。CPA被定位于人类染色体7q22----qter。同样，该探针用于追踪19个小鼠-中国仓鼠体细胞杂种中小鼠羧肽酶A（Cpa）基因的分离情况。Cpa被定位于小鼠染色体6。羧肽酶A基因是人和小鼠中保守的同线群的一部分。