Huang Binxin, Hao Xiaoting, Long Siyu, Ding Rui, Wang Junce, Liu Yan, Guo Sijia, Lu Jing, He Manxi, Yao Dezhong
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 611731, China.
School of Life Science and Technology, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 611731, China.
Brain Sci. 2021 Oct 9;11(10):1332. doi: 10.3390/brainsci11101332.
Some clinical studies have indicated that neutral and happy music may relieve state anxiety. However, the brain mechanisms by which these effective interventions in music impact state anxiety remain unknown.
In this study, we selected music with clinical effects for therapy, and 62 subjects were included using the evoked anxiety paradigm. After evoking anxiety with a visual stimulus, all subjects were randomly divided into three groups (listening to happy music, neutral music and a blank stimulus), and EEG signals were acquired.
We found that different emotional types of music might have different mechanisms in state anxiety interventions. Neutral music had the effect of alleviating state anxiety. The brain mechanisms supported that neutral music ameliorating state anxiety was associated with decreased power spectral density of the occipital lobe and increased brain functional connectivity between the occipital lobe and frontal lobe. Happy music also had the effect of alleviating state anxiety, and the brain mechanism was associated with enhanced brain functional connectivity between the occipital lobe and right temporal lobe.
This study may be important for a deep understanding of the mechanisms associated with state anxiety music interventions and may further contribute to future clinical treatment using nonpharmaceutical interventions.
一些临床研究表明,中性和欢快的音乐可能会缓解状态焦虑。然而,这些有效的音乐干预影响状态焦虑的大脑机制仍不清楚。
在本研究中,我们选择具有临床治疗效果的音乐,并采用诱发焦虑范式纳入62名受试者。在用视觉刺激诱发焦虑后,将所有受试者随机分为三组(听欢快音乐、中性音乐和空白刺激),并采集脑电图信号。
我们发现不同情绪类型的音乐在状态焦虑干预中可能有不同的机制。中性音乐具有缓解状态焦虑的作用。大脑机制表明,中性音乐改善状态焦虑与枕叶功率谱密度降低以及枕叶与额叶之间脑功能连接增加有关。欢快音乐也有缓解状态焦虑的作用,其大脑机制与枕叶和右颞叶之间脑功能连接增强有关。
本研究对于深入理解与状态焦虑音乐干预相关的机制可能具有重要意义,并可能进一步有助于未来使用非药物干预的临床治疗。