Yung Yuk-Lin, Fu Sai-Chuen, Cheuk Yau-Chuk, Qin Ling, Ong Michael Tim-Yun, Chan Kai-Ming, Yung Patrick Shu-Hang
Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.
Lui Che Woo Institute of Innovative Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.
Asia Pac J Sports Med Arthrosc Rehabil Technol. 2017 Jan 30;7:27-36. doi: 10.1016/j.asmart.2016.11.003. eCollection 2017 Jan.
Platelet concentrates (PC) generally refers to a group of products that are prepared from autologous blood intended to enhance healing activities. PC therapy is now very popular in treating musculoskeletal injuries; however, inconsistent clinical results urge the need to understand the working mechanism of PC. It is generally believed that the platelet-derived bioactive factors are the active constituents, and their bioavailability in the vicinity of the lesion sites determines the treatment efficacies. Therefore, the composition, localisation, and duration of the action of PC would be key determinants. In this review, we discuss how different preparations and delivery methods of PC would affect the treatment outcomes with respect to clinical evidence about PC therapy for osteoarthritis, tendinopathies, rotator cuff tears, anterior cruciate ligament injuries, and bone fractures. This review can be used as a quick guide for the use of PC therapy and provide insights for the further optimisation of the therapy in the near future.
血小板浓缩物（PC）通常指的是一组由自体血液制备而成、旨在增强愈合活性的产品。PC疗法目前在治疗肌肉骨骼损伤方面非常流行；然而，临床结果不一致促使人们需要了解PC的作用机制。一般认为，血小板衍生的生物活性因子是活性成分，它们在损伤部位附近的生物利用度决定了治疗效果。因此，PC的组成、定位和作用持续时间将是关键决定因素。在本综述中，我们根据关于PC疗法治疗骨关节炎、肌腱病、肩袖撕裂、前交叉韧带损伤和骨折的临床证据，讨论PC的不同制备方法和给药方式如何影响治疗结果。本综述可作为PC疗法使用的快速指南，并为在不久的将来进一步优化该疗法提供见解。
