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使用热疗和活体显微镜进行先进药物递送的小动物临床前研究。

Preclinical Studies in Small Animals for Advanced Drug Delivery Using Hyperthermia and Intravital Microscopy.

作者信息

Priester Marjolein I, Curto Sergio, Seynhaeve Ann L B, Perdomo Anderson Cruz, Amin Mohamadreza, Agnass Pierre, Salimibani Milad, Faridi Pegah, Prakash Punit, van Rhoon Gerard C, Ten Hagen Timo L M

机构信息

Laboratory Experimental Oncology (LEO), Department of Pathology, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.

Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.

出版信息

Cancers (Basel). 2021 Oct 14;13(20):5146. doi: 10.3390/cancers13205146.

DOI:10.3390/cancers13205146
PMID:34680296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8534089/
Abstract

This paper presents three devices suitable for the preclinical application of hyperthermia via the simultaneous high-resolution imaging of intratumoral events. (Pre)clinical studies have confirmed that the tumor micro-environment is sensitive to the application of local mild hyperthermia. Therefore, heating is a promising adjuvant to aid the efficacy of radiotherapy or chemotherapy. More so, the application of mild hyperthermia is a useful stimulus for triggered drug release from heat-sensitive nanocarriers. The response of thermosensitive nanoparticles to hyperthermia and ensuing intratumoral kinetics are considerably complex in both space and time. To obtain better insight into intratumoral processes, longitudinal imaging (preferable in high spatial and temporal resolution) is highly informative. Our devices are based on (i) an external electric heating adaptor for the dorsal skinfold model, (ii) targeted radiofrequency application, and (iii) a microwave antenna for heating of internal tumors. These models, while of some technical complexity, significantly add to the understanding of effects of mild hyperthermia warranting implementation in research on hyperthermia.

摘要

本文介绍了三种适用于通过对肿瘤内事件进行同步高分辨率成像来进行热疗临床前应用的设备。（临床前）临床研究已证实，肿瘤微环境对局部温和热疗的应用敏感。因此，加热是提高放疗或化疗疗效的一种有前景的辅助手段。更重要的是，温和热疗的应用是促使热敏纳米载体释放药物的一种有用刺激。热敏纳米颗粒对热疗的反应以及随之而来的肿瘤内动力学在空间和时间上都相当复杂。为了更好地了解肿瘤内的过程，纵向成像（最好具有高空间和时间分辨率）具有很高的信息量。我们的设备基于：（i）用于背部皮褶模型的外部电加热适配器，（ii）靶向射频应用，以及（iii）用于加热内部肿瘤的微波天线。这些模型虽然在技术上有些复杂，但显著有助于理解温和热疗的效果，值得在热疗研究中应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/b40d15aeea34/cancers-13-05146-g015.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/49c9a4b4588e/cancers-13-05146-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/33f18dfc6f83/cancers-13-05146-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/a8cb4c9e1d4f/cancers-13-05146-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/937f9a73fa14/cancers-13-05146-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/88b0606cebc6/cancers-13-05146-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/7da13420f579/cancers-13-05146-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/f357a5f47e7b/cancers-13-05146-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/919b8386950e/cancers-13-05146-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/f11f3f057789/cancers-13-05146-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/b40d15aeea34/cancers-13-05146-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/f31de947b54a/cancers-13-05146-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/7815514460cf/cancers-13-05146-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/f7e3b7e2134c/cancers-13-05146-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/867d8fc3f0d4/cancers-13-05146-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/49c9a4b4588e/cancers-13-05146-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/33f18dfc6f83/cancers-13-05146-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/a8cb4c9e1d4f/cancers-13-05146-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/937f9a73fa14/cancers-13-05146-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/b6ca7d872530/cancers-13-05146-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/88b0606cebc6/cancers-13-05146-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/7da13420f579/cancers-13-05146-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/f357a5f47e7b/cancers-13-05146-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/919b8386950e/cancers-13-05146-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/f11f3f057789/cancers-13-05146-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bd/8534089/b40d15aeea34/cancers-13-05146-g015.jpg

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Cancers (Basel). 2021 Mar 12;13(6):1243. doi: 10.3390/cancers13061243.
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