Chu Pei-Yi, Tzeng Yen-Dun Tony, Chiu Yi-Han, Lin Hung-Yu, Kuo Chen-Hsin, Hou Ming-Feng, Li Chia-Jung
College of Medicine, National Chung Hsing University, Taichung 402, Taiwan.
Department of Pathology, Show Chwan Memorial Hospital, Changhua 500, Taiwan.
Biomedicines. 2021 Sep 26;9(10):1329. doi: 10.3390/biomedicines9101329.
E3 ubiquitin-linked enzyme MARCH5, also known as membrane-associated circular finger 5, is an enzyme encoded by the human gene. The main objective of this study was to visualize the prognosis of in breast cancer and to determine the relationship between expression and tumor immunity. MARCH5 expression was significantly higher in several cancers, including breast cancer (BRCA), compared with corresponding normal tissues. Not only was high expression associated with poorer overall survival, but also expression was positively correlated with the number of tumor-infiltrating immune cells in BRCA malignant tissues. Furthermore, expression showed a strong correlation with various immune markers of BRCA, suggesting its role in regulating tumor immunity. MARCH5 is a useful prognostic biomarker in several cancers, and its expression is highly correlated with tumor immune cell infiltration, and increased expression may serve as a new biomarker for BRCA diagnosis and prognosis.
E3泛素连接酶MARCH5，也称为膜相关环指蛋白5，是一种由人类基因编码的酶。本研究的主要目的是评估MARCH5在乳腺癌中的预后情况，并确定其表达与肿瘤免疫之间的关系。与相应的正常组织相比，MARCH5在包括乳腺癌（BRCA）在内的几种癌症中表达显著更高。不仅高MARCH5表达与较差的总生存期相关，而且MARCH5表达与BRCA恶性组织中肿瘤浸润免疫细胞的数量呈正相关。此外，MARCH5表达与BRCA的各种免疫标志物显示出强烈的相关性，表明其在调节肿瘤免疫中的作用。MARCH5在几种癌症中是一种有用的预后生物标志物，其表达与肿瘤免疫细胞浸润高度相关，MARCH5表达增加可能作为BRCA诊断和预后的新生物标志物。
