Multi-Omics Reveals the Immunological Role and Prognostic Potential of Mitochondrial Ubiquitin Ligase MARCH5 in Human Breast Cancer.

E3 ubiquitin-linked enzyme MARCH5, also known as membrane-associated circular finger 5, is an enzyme encoded by the human gene. The main objective of this study was to visualize the prognosis of in breast cancer and to determine the relationship between expression and tumor immunity. MARCH5 expression was significantly higher in several cancers, including breast cancer (BRCA), compared with corresponding normal tissues. Not only was high expression associated with poorer overall survival, but also expression was positively correlated with the number of tumor-infiltrating immune cells in BRCA malignant tissues. Furthermore, expression showed a strong correlation with various immune markers of BRCA, suggesting its role in regulating tumor immunity. MARCH5 is a useful prognostic biomarker in several cancers, and its expression is highly correlated with tumor immune cell infiltration, and increased expression may serve as a new biomarker for BRCA diagnosis and prognosis.