液体活检作为口腔癌患者场癌变效应特征化和早期检测的工具
Liquid Biopsy as a Tool for the Characterisation and Early Detection of the Field Cancerization Effect in Patients with Oral Cavity Carcinoma.
作者信息
Pérez-Ruiz Elisabeth, Gutiérrez Vanesa, Muñoz Marta, Oliver Javier, Sánchez Marta, Gálvez-Carvajal Laura, Rueda-Domínguez Antonio, Barragán Isabel
机构信息
Unidad de Gestión Clínica Intercentros de Oncología Médica, Oncology Department, Institute of Biomedical Investigation of Malaga (IBIMA), Hospitales Universitarios Regional y Virgen de la Victoria, 29010 Malaga, Spain.
Researcher Unit, Unidad de Gestión Clínica Intercentros de Oncología Médica, Institute of Biomedical Investigation of Malaga (IBIMA), Hospitales Universitarios Regional y Virgen de la Victoria, 29010 Malaga, Spain.
出版信息
Biomedicines. 2021 Oct 15;9(10):1478. doi: 10.3390/biomedicines9101478.
Oral squamous cell carcinoma (OSCC) constitutes approximately 25% of all head and neck cancer, for which the consumption of tobacco and alcohol are the main associated risk factors. The field cancerization effect of OSCC is one of the main reasons for the poor survival rates associated with this disease. Despite some advances, its ccharacterization and early diagnosis continue to challenge modern oncology, and the goal of improving the prognosis remains to be achieved. Among new early diagnostic tools for OSCC that have been proposed, liquid biopsy appears to be an ideal candidate, as studies have shown that the analysis of blood and saliva provides promising data for the early detection of relapses or second tumours.
口腔鳞状细胞癌（OSCC）约占所有头颈癌的25%，吸烟和饮酒是其主要相关风险因素。OSCC的场癌化效应是导致该疾病生存率低的主要原因之一。尽管取得了一些进展，但其特征描述和早期诊断仍然是现代肿瘤学面临的挑战，改善预后的目标仍有待实现。在已提出的OSCC新型早期诊断工具中，液体活检似乎是一个理想的选择，因为研究表明，血液和唾液分析为复发或继发性肿瘤的早期检测提供了有前景的数据。
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